by Keila DePape, McGill University a, The mouse model of BCG vaccination and IAV infection. b,c, Morbidity and mortality of mice infected with the lethal dose of PR8 (120 PFUs; n = 9–10). d, Viral load at various timepoints after infection with a sublethal dose of IAV-PR8 (50 PFUs; n = 4–8). e, Confocal microscopy of lung section infected with...
by Elana Gotkine CD19 chimeric antigen receptor (CAR) T-cell therapy seems feasible, safe, and efficacious for patients with different autoimmune diseases, according to a study published in the Feb. 22 issue of the New England Journal of Medicine. Fabian Müller, M.D., from the Friedrich-Alexander University Erlangen-Nürnberg in Germany, and colleagues examined patients with severe systemic...
by Valerie Goodwin, University of Michigan Credit: Jacob Dwyer, Justine Ross / Michigan MedicineSystemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health researchers have studied the pathology of systemic sclerosis to understand better the disease and...
Reports and Proceedings KAROLINSKA INSTITUTET ANDERS KJELLBERGCREDIT: MARTIN STENMARK High-dose pressurized oxygen can stress out old immune cells, leaving behind a younger, better functioning immune system. It helped with acute COVID, and now Anders Kjellberg is testing the method for post-covid as well. Hyperbaric oxygen therapy, giving patients 100 percent oxygen at a pressure corresponding...
by Cold Spring Harbor Laboratory Graphical abstract. Credit: Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.01.007Our immune system is remarkably powerful. It quickly assembles teams of cells to eliminate threats inside our bodies. But sometimes, it hits the wrong target. Autoimmune diseases like lupus and multiple sclerosis result from friendly fire—immune cells attacking healthy tissues and organs by mistake....
Gwendolyn Rak Neurologic damage following acute viral infections may be attributed to an excessive immune response to the infection, according to a new study.Many viral infections that don’t directly infect the central nervous system (CNS) have been associated with severe neurologic disease. For these viruses, including newer viruses such as SARS-CoV-2 and Zika, the mechanism...
by Ghent University Longitudinal images of an affected joint. Credit: Nature Medicine, DOI: 10.1038/s41591-024-02822-0Researchers at Ghent University Hospital, Ghent University, and VIB-UGent Center for Inflammation Research, show that antibody therapy can be effective against erosive hand osteoarthritis. Using the antibody denosumab leads to bone remodeling and the prevention of erosive joint damage. This is the first...
by Hackensack Meridian Health Antibody responses based on diagnostic cohorts. Credit: Microbiology Spectrum (2024). DOI: 10.1128/spectrum.02050-23First-year Hackensack Meridian School of Medicine (HMSOM) student Elizabeth Titova leveraged her background in phlebotomy and scientific research to publish a new clinical study around COVID-19 vaccination in Microbiology Spectrum. In her study, Titova found that while naturally stronger in...
A cigarette habit and previous infection with a common virus both have important effects on the immune system. By Heidi LedfordClose up of a man as he smokes a cigarette in Sundbyberg, near Stockholm.The immune-system signature of cigarette smoking persists for many years after a person kicks the habit.Credit: Jonathan Nackstrand/AFP via Getty The impacts...
New anti-cancer therapies could simultaneously deplete tumors of energy and boost the body’s immune response against them. (CREDIT: Creative Commons) Tumor cells are notorious for their adaptability and resilience in the face of treatment, often reshaping their energy metabolism to fuel their rapid growth and invasion. This metabolic shift not only sustains cancer cells but...
