by Dartmouth Health The association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Sex, chronological age, ancestry, and disease status were adjusted (*FDR < 0.05, **FDR < 0.01, ***FDR < 0.001). Credit: Aging Cell (2023). DOI: 10.1111/acel.14071When asked, “How old are you?” Most people measure by...
by Emily Ayshford, University of Chicago Whole-tissue gene expression reveals the molecular effects of sepsis and endotoxemia across organs. a, Schematic overview of the experimental workflow. b, Heat map of DEGs (rows) from whole-tissue mRNA profiles ordered by k-means clustering (horizontal lines), organ types (top; colors) and time periods (bottom; tick marks for 0.25, 0.5, 1,...
by Technical University Munich Intestinal tissue during a graft-versus-host reaction: Donor cells (red) attack the body of the patient. Credit: Sebastian Jarosch, Dirk Busch / TUMAfter stem cell transplantation, the donated immune cells sometimes attack the patients’ bodies. This is known as graft versus host disease or GvHD. Researchers at the Technical University of Munich (TUM)...
by Monash University Credit: Pixabay/CC0 Public DomainIn a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia have cracked the code behind Ikaros, an essential protein for immune cell development and protection against pathogens and cancer. This disruptive research, led by the eminent Professor Nicholas Huntington...
By Paul McClure Researchers have harnessed the cancer-destroying abilities of the body’s natural killer cells Depositphotos Researchers have made a breakthrough in cancer treatment by harnessing the disease-destroying abilities of the body’s natural killer cells. Their novel nanodrones selectively target a tumor, enabling the killer cells to do what they do best: Suppress cancer growth. The...
by Zhang Nannan, Chinese Academy of Sciences SARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao’s groupIn the past four years, the pathogen responsible for Coronavirus Disease 2019 (COVID-19), SARS-CoV-2, has infected more than 770 million people and caused more than 6.9 million deaths worldwide. The severe impact of SARS-CoV-2 is often attributed to...
by Delthia Ricks , Medical Xpress Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainMedical investigators are theorizing that a combination of two treatments that activate myeloid cells may effectively treat a recalcitrant form of pancreatic cancer that thwarts conventional immunotherapy. Mobilizing the immune system to destroy cancers has...
Hallie Levine A treatment used to treat acute COVID-19 infection has also been found to be effective against long COVID, a new small study has found. The research, which assessed the benefits of monoclonal antibodies, suggests relief may finally be ahead for millions of Americans with long COVID for whom treatment has remained elusive. The...
by Felicia Lindberg, Karolinska Institutet Credit: Pixabay/CC0 Public Domain Researchers at Karolinska Institutet and Danderyd Hospital have followed recipients of the new updated COVID-19 vaccine and analyzed the antibody response to different SARS-CoV-2 variants. The results show a surprisingly strong response to the now dominant and highly mutated omicron variants. The ongoing COMMUNITY study, which was...
Patricia Weiser, Pharm.D. Vaccine technology is rapidly growing in the pharmaceutical industry, with therapy options expanding in response to areas of clinical need. One area of focus is the development of vaccines targeting cancer. Cancer vaccines generally fall into two categories: preventive and active treatment. Preventive cancer vaccines are currently more established and focus on...
