Some patients with metastatic prostate cancer respond to a combination of immune checkpoint inhibitors after hormonal therapy and chemotherapy have failed, according to early results from a clinical trial led by investigators at The University of Texas MD Anderson Cancer Center presented today at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San...
Category: <span>Immunology</span>
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Regulating the MS-causing properties of Th17 cells
Th17-cell differentiation. Satb1 is dispensable for the differentiation of Th17 cells but plays a pivotal role in the effector functions of pathogenic Th17 cells. EurekAlert! An international study group led by researchers from Osaka University identifies a protein regulator responsible for inducing the pathogenic properties of Th17 cells, leading to multiple sclerosis and other inflammatory...
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Decoding the human immune system
For the first time ever, researchers are comprehensively sequencing the human immune system, which is billions of times larger than the human genome. In a new study published in Naturefrom the Human Vaccines Project, scientists have sequenced a key part of this vast and mysterious system—the genes encoding the circulating B cell receptor repertoire. TechGenYZ...
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Sea worms and jellyfish treat cancer and kill insects
Scientists of the Pacific Institute of Bioorganic Chemistry (PIBOC) of the Far Eastern Branch of the Russian Academy of Sciences (FEB RAS) and the Far Eastern Federal University (FEFU) found out marine invertebrates living in Troitsa Bay, the Sea of Japan, contain biologically active compounds with strong antitumor and antimicrobial properties, and also capable of...
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Surprise rheumatoid arthritis discovery points to new treatment for joint inflammation
Researchers at the University of Virginia School of Medicine have identified an unexpected contributor to rheumatoid arthritis that may help explain the painful flare-ups associated with the disease. The discovery points to a potential new treatment for the autoimmune disorder and may also allow the use of a simple blood test to detect people at...
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Cells that destroy the intestine
More than 4000,000 people in Germany are affected by the chronic inflammatory bowel diseases Morbus Crohn or ulcerative colitis. Patients often suffer from flare-ups, which damage intestinal tissue. In spite of tremendous advances in treating the diseases with medication, the chronic inflammation still cannot be kept sufficiently in check for a number of patients. Until...
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Intestinal immune cells play key role in metabolic regulation, cardiovascular health
A Massachusetts General Hospital (MGH) research team has identified what appears to be an important checkpoint in dietary metabolism, a group of cells in the small intestine that slow down metabolism, increasing the amount of ingested food that is stored as fat rather than being quickly converted into energy. In the report published in Nature...
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Skin cancer can spread in mice by hijacking the immune system
Targeting these molecules with inhibiting drugs could help to prevent this aggressive skin cancercoming back after treatment. Credit: CC0 Public Domain Scientists have uncovered molecules released by invasive skin cancer that reprogram healthy immune cells to help the cancer to spread. The findings of the Cancer Research UK-funded study are published in Cell, today. Researchers...
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Machine learning finds multiple factors underlie cancer immunotherapy success
A University of Maryland-led research team is using a branch of artificial intelligence known as machine learning to better target immunotherapy treatment to those who will benefit. A pair of cytoxic T cells (in red), part of the body’s immune system, attack an oral cancer cell. Credit: NCI/Duncan Comprehensive Cancer Center at Baylor College of...
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Messages for increasing parental confidence in HPV vaccine ID’d
Parth D. Shah, Pharm.D., Ph.D., from the Fred Hutchinson Cancer Research Center in Seattle, and colleagues surveyed a national sample of 1,196 U.S. parents of children aged 9 to 17 years in 2017 to 2018. The researchers recorded brief videos of a pediatrician providing messagesthat addressed seven HPV vaccination topics that often elicit questions or...