Formation of extracellular structures from white blood cells, after stimulation with ANCA autoantibodies. Researchers from Charité—Universitätsmedizin Berlin have been able to improve their understanding of the key mechanism involved in the pathogenesis of a serious autoimmune disease. For the first time, researchers were able to demonstrate a close link between the activation of programmed...
Category: <span>Immunology</span>
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A non-invasive computational imaging approach may predict response to immunotherapy
A computational imaging-based signature of immune-cell infiltration in and around a tumor could predict patients’ responses to treatment with anti-PD1/PDL1 immunotherapies, according to data from a study presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 26-30. “Immunotherapy, a recent modality of treatment in oncology, has profoundly changed the management...
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Scientists discover surprising immune cell activity that may be limiting immunotherapy
Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment. Treg cells work within the immune system to suppress immune function. It’s a normal process: T cells fight an infection and when the threat is over, Treg cells send the signal to stand...
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Researchers reveal the role of a DNA repair mechanism
Fernando Gómez Herreros and his research team. Researchers from the University of Seville, in collaboration with the Genome Damage and Stability Centre of the University of Sussex in the United Kingdom, have recently published a study in the review Nature Communications, in which they make an important step forward in understanding more exactly what the...
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RNA Editing Possible with CRISPR-Cas13
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. WIKIMEDIA, NICOLLE RAGER, NATIONAL SCIENCE FOUNDATION Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR),...
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RNA Editing Possible with CRISPR-Cas13
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR), is described today (October 25)...
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Immunotherapy with peptides
Abstract Specific allergen immunotherapy is clinically effective and disease modifying. It has a duration of effect that exceeds the treatment period and prevents both the progression of allergic rhinitis to asthma and the acquisition of new allergic sensitizations. However, immunotherapy is associated with a high frequency of adverse events related to the allergenicity of vaccines....
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Details uncovered in development of immune cell implicated in cancer, autoimmune diseases
While the immune system is critical for fighting off invading micro-organisms, sometimes it can turn against the body and attack healthy tissues or be involved in cancer cell growth. A study by University of North Carolina Lineberger Comprehensive Cancer Center researchers provides new details about the development of a particular immune cell that can play...
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Scientists Find a Role for Parkinson’s Gene in the Brain
A new study published in the journal Neuron sheds light on the normal function of LRRK2, the most common genetic cause for late-onset Parkinson’s disease. The study was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. For more than 10 years, scientists have known that mutations in...
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Closest Look Yet at Killer T-cell Activity Could Yield New Approach to Tackling Antibiotic Resistance
ANN ARBOR — In a study that could provide a roadmap for combatting the rising threat of drug-resistant pathogens, researchers have discovered the specific mechanism the body’s T cells use to kill bacteria. University of Michigan researchers, in collaboration with colleagues at Harvard University, have discovered a key difference between the way immune cells attack...