Scientists have created hollow, spherical sacks called vesicles by using protein and RNA. These bubble-like entities—which form spontaneously when specific protein and RNA molecules mix in an aqueous buffer solution—hold potential as biological storage compartments. They could serve as an alternative to traditional vesicles that are made from water-insoluble organic compounds called lipids, researchers say....
Category: <span>Microbiology</span>
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How microbiome multi-omics can bolster human health
Sequencing technologies are enabling a deeper analysis of the gut’s microbiome. Researchers can now explore what our microbial inhabitants are doing and how they contribute to, or protect from, disease. investigator of the Human Microbiome Bioactives Resource (HMBR), which provides platforms and methods to integrate 16S sequencing, shotgun metagenomics, metatranscriptomics and meta-metabolomics for microbiome discovery....
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Gut Piezo1 regulates gut and bone homeostasis via RNA sensing.
NATIONAL INSTITUTES OF NATURAL SCIENCES SCHEMATIC MODEL OF FECAL RNA-MEDIATED SEROTONIN PRODUCTION. view more CREDIT: KENTA MARUYAMA In a new study published in Cell, “RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis”, a research team led by Kenta Maruyama M.D., Ph.D. from National Institute for Physiological Sciences (NIPS) explored the role of...
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Universal gut microbiome-derived signature predicts cirrhosis
by University of California – San Diego Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide, affecting an estimated one-quarter of the global population. It is a progressive condition that, in worst cases, can lead to cirrhosis, liver cancer, liver failure and death. In a new paper published online June...
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Parkinson’s linked to overabundance of opportunistic gut pathogens
By Nick Lavars June 21, 2020 As a disease without a cure or means of prevention, there is a lot we don’t know about Parkinson’s and the way it takes hold in the human body. One school of thought is that it actually begins in the gut, and a new study has strengthened these ties...
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Molecules that reduce ‘bad’ gut bacteria reverse narrowing of arteries in animal study
by The Scripps Research Institute Scientists at Scripps Research have developed molecules that can remodel the bacterial population of intestines to a healthier state and they have shown—through experiments in mice—that this reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis. The scientists, who report their findings in Nature Biotechnology, created a...
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Improved gut microbiota with cholesterol-lowering medication
by Margareta Gustafsson Kubista, University of Gothenburg There is a clear link between improved gut microbiota and one of our most common cholesterol-lowering drug groups: statins. This is evident from a European study involving researchers from the University of Gothenburg. Scientists have previously found an association between the gut microbiota and various metabolism-related and cardiovascular...
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The Parkinson’s disease gut has an overabundance of opportunistic pathogens
by Jeff Hansen, University of Alabama at Birmingham Parkinson’s disease is a common, progressive and debilitating neurodegenerative disease. It currently cannot be prevented or cured. In 2003, Heiko Braak proposed that non-inherited forms of PD are caused by a pathogen in the gut. He hypothesized that the pathogen could pass through the intestinal mucosal barrier...
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High-salt diet impacts health of gut microbiome
AUGUSTA, Ga. (June 9, 2020) – Particularly in females with untreated hypertension, reducing salt intake to what’s considered a healthier level appears to be good for both their gut microbiome and their blood pressure, scientists report. In the blood of 145 adults with untreated hypertension, the scientists found that, particularly for the females, just six...
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Study shows patients with hemorrhagic brain disease have disordered gut microbiomes
by University of Chicago Medical Center A new study shows that people with a rare genetic disease that causes bleeding in the brain have gut microbiomes distinct from those without the disease. Moreover, it is the molecules produced by this bacterial imbalance that cause lesions to form in the brains of these patients. The results...