by New York University Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice. Credit: Bunnett Lab Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does...
Category: <span>Pain/Inflammation</span>
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Anti-obesity drug has life-changing benefits for arthritis
Osteoarthritis, which causes stiff and painful joints, affects the knees most often.Credit: Dr. P. Marazzi/Science Photo Library A blockbuster weight-loss drug sharply reduces pain from obesity-related knee arthritis and improves a person’s ability to engage in activities such as walking. That’s according to a clinical trial conducted in 11 countries — the first of its kind to...
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Methotrexate May Prevent Rheumatoid Arthritis Development in Subset of ACPA–Negative Patients
A 1-year course of methotrexate (MTX) in clinically suspected arthralgia may prevent the development of rheumatoid arthritis (RA) in at-risk individuals who test negative for anti-citrullinated protein antibody (ACPA), according to 4-year results from the TREAT EARLIER study. While 2-year data did not show a preventive effect, researchers risk-stratified patients in this most recent data. The previous study also grouped...
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“Bizarre” way ant venom hits a nerve: An exciting new path to pain relief
Ant venom mechanism provides new clues to how we treat pain Depositphotos View 3 Images View gallery – 3 images Insect venom may seem like an unlikely ally in the discovery of new human pain treatments, but the latest findings into the “unique” way a small ant causes us such agony is a big leap...
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Chronic pain can be predicted within three days of an injury
Lasting pain is linked to anxiety and how much two brain regions talk about the injury Northwestern University CHICAGO — After only one to three days of a whiplash injury, scientists can predict which patients will develop chronic pain based on the extent of cross ‘talk’ between two regions of the brain, and the person’s...
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Study finds genetics, not lifestyle, is a major cause of gout
Linking of insulin signaling, the tricarboxylic acid cycle and epigenomic reprogramming cellular pathways with candidate gout-associated genes. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01921-5 A major international study has found that gout is a chronic illness in which genetics is a major cause, rather than the lifestyle choices of the sufferer. Led by University of Otago researchers, the genome-wide...
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New clinical model for predicting hip fractures could save lives
Standardized individual 5-year risk of hip fracture according to age at baseline in all women and by different risk factors. Estimates were obtained using flexible parametric survival models with baseline knots placed at the 25th, 50th, and 75th percentile of the uncensored log survival times. Credit: eClinicalMedicine (2024). DOI: 10.1016/j.eclinm.2024.102877 Researchers at Uppsala University have developed a...
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People with hip osteoarthritis are unable to activate their muscles as efficiently, irrespective of strength
Muscle activation in people suffering from hip osteoarthritis might be a case of “mind over matter,” new research from Edith Cowan University (ECU) has shown. Research undertaken by ECU post-doctoral research fellow Dr. Myles Murphy investigated muscle function in people with hip osteoarthritis and found that these patients were unable to activate their muscles as efficiently. The...
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Review of performance measures for pain finds those for acute pain treatment lacking
September 24, 2024 by American College of Physicians Credit: CC0 Public DomainA review by the American College of Physicians (ACP) of performance measures designed to evaluate quality of care for those adults suffering from pain found three of six measures relevant to internal medicine physicians to be valid. “Quality Indicators for Pain in Adults: A...
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New study shows durability of minimally invasive procedure to combat knee pain
September 23, 2024 by Society of Interventional Radiology Credit: Journal of Vascular and Interventional Radiology (2024). DOI: 10.1016/j.jvir.2024.08.028A new study shows that a minimally invasive treatment for osteoarthritis (OA) in the knees may have a lasting benefit of at least 2 years. Published today in the Journal of Vascular and Interventional Radiology during Pain Awareness...