by Tel-Aviv University α-synuclein spread in the mouse brain. Credit: Tel Aviv University. Researchers at Tel Aviv University (TAU) discovered a new factor in the pathology of Parkinson’s disease, which in the future may serve as a target for developing new treatments for this terrible ailment, affecting close to 10 million people worldwide. The researchers say,...
Category: <span>parkinsons</span>
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RNA structures present a promising target for early intervention in Parkinson’s disease
by Kumamoto University The trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α-Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α-synuclein aggregation, helping to protect against...
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Closing in on Parkinson’s Disease proteins in extracellular vesicles in the blood
Precision diagnostics for diseases that affect the brain and other organs brought closer by new ability to exclusively access contents of organ-derived extracellular vesicles in blood Peer-Reviewed Publication Wyss Institute for Biologically Inspired Engineering at Harvard image: The team’s overall goal was to be able to compare the amounts of α-synuclein protein contained in extracellular...
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Rapid horizontal eye movement can improve stability in people with Parkinson’s
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO Rapid side-to-side eye movements can help stabilize posture, avoid falls and maintain balance for people with Parkinson’s disease, just as they can for healthy people. This seemingly counterintuitive conclusion was reached by researchers at São Paulo State University (UNESP) in Brazil and the University of...
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Parkinson’s disease a promising treatment- pharmaceutical
Parkinson’s disease: finally a promising treatment© Unsplash A sparkling shot… almost magical, to treat Parkinson’s. American researchers have conducted several clinical trials, rather encouraging. Gold nanocrystals that could restore molecules affected by neurodegenerative diseases? Really? To understand how they work, let’s take a quick look at “biology”. The brain, in order to function properly, needs a...
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Hearing loss linked to increased Parkinson’s risk in veterans
by Justin Jackson , Medical Xpress Credit: Pixabay/CC0 Public Domain Oregon Health & Science University-led researchers have found a correlative link between hearing loss and the development of Parkinson’s disease (PD). They find the risk of PD rises somewhat with the severity of hearing loss, and declines when hearing aids are promptly issued. Previous studies...
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FDA approves Vyalev for advanced Parkinson’s disease
by Lori Solomon The U.S. Food and Drug Administration has approved AbbVie’s Vyalev (foscarbidopa and foslevodopa) for adults living with advanced Parkinson’s disease (PD). Vyalev is the first and only subcutaneous 24-hour continuous infusion of levodopa-based therapy for the treatment of motor fluctuations in advanced PD and allows for personalized dosing throughout the day based...
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Parkinson’s disease may one day be treated with a shot of magnetic discs
This diagram illustrates how the hexagonal MENDs discs (top) are able to electrically stimulate a neuron (pink) MIT View 2 Images Although brain-implanted electrodes do help minimize the effects of Parkinson’s disease and other neurological disorders, implanting and activating those electrodes can be a tricky process. That’s why scientists are now developing an alternative, in the form...
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For people with Parkinson’s, moving is a mental challenge as well as a physical one
Distribution of participant scores on different tasks. (A) Index scores generated from mental chronometry of the box and blocks task are shown for the more affected versus less affected side. (B) Density plots represent distribution of index scores and our predictors of interest. Credit: Brain and Cognition (2024). DOI: 10.1016/j.bandc.2024.106181 It’s well known that Parkinson’s disease can...
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Scientists use stem cells to recreate a hallmark of Parkinson’s disease in human neurons
Slide showing the development of Lewy bodies. Credit: Armin Bayati from Peter McPherson Lab, The Neuro Lewy bodies are a hallmark of Parkinson’s disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to developing better treatments. A study from The Neuro (Montreal Neurological Institute-Hospital) of McGill University, in collaboration...