For a while now, heart disease researchers have known that a protein called GRK5 – expressed throughout the body, though most notably in the lungs, heart, and placenta – normally dwells in the outer membrane of heart cells and, upon exposure to stress, moves into the cell nucleus, switching on a host of genes that lead to cardiomyopathy (thickening...
by University of California – San Diego Cancer cell during cell division. Credit: National Institutes of Health Every 12 minutes, someone in the United States dies of pancreatic cancer, which is often diagnosed late, spreads rapidly and has a five-year survival rate at approximately 10 percent. Treatment may involve radiation, surgery and chemotherapy, though often the...
by Brian Flood, University of Illinois at Chicago Double-faced peptide-based boosters are computationally designed to allow recognition of SARS-CoV-2 (grey, schematic) by Hepatitis B antibodies. One booster face made of ACE2-mimic peptides (red) can bind to the receptor binding domain of SARS-CoV-2 (blue). The other booster face composed of a Hepatitis B core-antigen (orange) can target...
by Beth Israel Deaconess Medical Center Credit: Pixabay/CC0 Public Domain Renal cell carcinoma (RCC) is the most common form of kidney cancer. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide. Currently, the 5-year survival rate for patients with metastatic RCC is only about 12 percent....
RUSH UNIVERSITY MEDICAL CENTER A new therapy developed by researchers at Rush University Medical Center is showing success as a way to prevent COVID-19 symptoms in mice. In a study published in the Journal of Neuroimmune Pharmacology, mouse models with COVID-19 showed positive results when a small peptide was introduced nasally. The peptide proved effective in reducing fever, protecting...
NATIONAL RESEARCH COUNCIL OF SCIENCE & TECHNOLOGY IMAGE: A SCHEMATIC DIAGRAM OF THE APPLICATION OF CANCER-TARGETED SUPERMOLECULAR PEPTIDE PHOTOTHERAPY DRUGS TO ANIMAL EXPERIMENTS DEVELOPED BY KIST RESEARCHERS. A SINGLE SUPERMOLECULAR PEPTIDE PHOTOTHERAPY INJECTION AND REPEATED PHOTOTHERAPY WERE USED TO COMPLETELY TREAT CANCER. CREDIT: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY(KIST) Researchers in South Korea have developed a phototherapy technology...
by Purdue University Elizabeth Topp, a Purdue professor of physical and industrial pharmacy, helped develop a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Credit: Chris Adam/Purdue University A novel form of a drug used to treat osteoporosis that comes with the potential for fewer side effects may...
by eLife Credit: CC0 Public Domain Scientists have shown that adding an experimental cancer drug to a widely used diabetes treatment improves blood glucose control and weight loss in mice, according to a study published today in eLife. The results pave the way for clinical studies of the new drug combination as a more effective long-term treatment...
by Ohio State University Medical Center A study led by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor. Published in the journal Oncoimmunology, on October 1, 2020, the findings...
“Position 4” didn’t seem important until researchers took a long look at a particular peptide. That part of the peptide drawn from a SARS-CoV virus turned out to have an unexpected but significant influence on how it stably binds with a receptor central to the immune system’s ability to attack diseased cells. In a study published by the Proceedings of the National...
