Engineered peptides provide efficient, non-toxic delivery of gene-editing proteins to airway cells UNIVERSITY OF IOWA HEALTH CARE News of advances in gene-editing technology raises the prospect of actually using this approach to treat disease in patients. But one of the hurdles that remains is how to deliver these tools to the right cells in the patients safely and efficiently. Scientists led by University of Iowa researcher Paul...
Category: <span>Peptides</span>
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Researchers find new signaling systems in human cells
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES The human cell has a wide variety of receptors on its surface that many molecules and therapeutic drugs can bind to in order to activate signals inside the cell to regulate different physiological functions. GPCRs are the largest – and a very important – family of receptors...
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Silencing RNA nanotherapy shows promise against pancreatic cancer
by University of South Florida Despite advances in cancer survival, more than 90 percent of people with pancreatic cancer die within five years. Most patients with pancreatic tumors (and half of those with colorectal cancers) carry a mutation in the KRAS gene, which normally controls cell growth and death. The KRAS oncogene was discovered more...
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Antibiotic produced by the microbiome kills bacteria by disturbing energy metabolism
GERMAN CENTER FOR INFECTION RESEARCH A research team from the Universities of Tübingen and Göttingen as well as from the German Center for Infection Research has investigated the mode of action of a new class of antibiotics that is highly effective against multidrug-resistant pathogens. The so-called fibupeptides impair the energy supply to the bacterial cell, consequently causing...
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Sea worms and jellyfish treat cancer and kill insects
Scientists of the Pacific Institute of Bioorganic Chemistry (PIBOC) of the Far Eastern Branch of the Russian Academy of Sciences (FEB RAS) and the Far Eastern Federal University (FEFU) found out marine invertebrates living in Troitsa Bay, the Sea of Japan, contain biologically active compounds with strong antitumor and antimicrobial properties, and also capable of...
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Too much of this in the blood could predict unhealthy aging
A hormone found in the blood that’s commonly linked to heart disease also might signal when someone is more likely to grow weaker or lose their ability to balance before they’re 70. People in their early 60s with higher-than-normal levels of brain natriuretic peptide, or BNP, walked slower and were less able to raise themselves...
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The Intestine Responds to Heart Failure by Enhanced Mitochondrial Fusion through Glucagon-like Peptide-1 Signaling
Aims Glucagon-like peptide-1 (GLP-1) is a neuroendocrine hormone secreted by the intestine. Its receptor (GLP-1R) is expressed in various organs, including the heart. However, the dynamics and function of the GLP-1 signal in heart failure remains unclear. We investigated the impact of the cardio-intestinal association on hypertensive heart failure using miglitol, an α-glucosidase inhibitor known...
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A Modular Vaccine Platform Combining Self-Assembled Peptide Cages and Immunogenic Peptides
Abstract Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self‐adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self‐assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles...
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Corticotropin-Releasing Hormone (CRH)
Corticotropin–releasing hormone (CRH), also called corticotropin–releasing factor (CRF), is a peptide hormone that activates the synthesis and release of adrenocorticotropic hormone (ACTH) from the pituitary gland. In this way, CRH affects our response to stress, addiction and depression, among others. What is Corticotropin-Releasing Hormone? CRH is a neuropeptide hormone that regulates neuroendocrine, sympathetic, and behavioral functions in response to stress. It consists of 41 amino acids...
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Could it be possible to eliminate clogged arteries?
A new clinical trial to study a potential way of reducing the risk of early-onset atherosclerosis may be on the way. After evaluating previous research, a report published in the Journal of the American Heart Association concludes that a clinical trial might pave the way for a new treatment to help reduce the early onset...