August 20, 2024 by Sichuan International Medical Exchange and Promotion Association Modifications Involved in The Process of Gene Expression: From Transcription to Protein Activation and Depolymerization. Numerous processes are involved in gene expression. Histone modifications facilitate DNA transcription. DNA, in turn, undergoes modifications within proteins. mRNA modification is employed for nuclear and cytoplasmic localization. Once...
News Release 10-Sep-2024 “For the first time, the present study revealed a critical role for protein palmitoylation in the development of a DNA damage-induced senescence phenotype.” Peer-Reviewed PublicationImpact Journals LLC image: Figure 4. The influence of 2-BP treatment on the levels of senescence markers. The levels of p-p53 (A), HMGB1 (B), and lamin B1 (C)...
JULY 25, 2024 by University of Otago Model of the oxidation-induced amyloid formation and disassembly mechanism of p16. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49581-7Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis...
JULY 12, 2024 by Weizmann Institute of Science Cells with cancer-causing p53 proteins (red); the genetic material in the cell nuclei is in blue. Left: In the presence of a regular DNAJA2 chaperone, the structure of the p53 proteins is stabilized, so they do not bind with one another and therefore remain scattered throughout the...
JULY 11, 2024 by Josh Baxt, UC Davis INBRX-101 is engineered to maximize the functional activity of AAT, particularly in the lung. Credit: UC DavisA multicenter safety study at UC Davis Health tested a protein drug (INBRX-101), developed to improve care for people with alpha-1 antitrypsin deficiency (AATD), and showed the therapy is quite safe....
The removal of the protein BECLIN1 causes a condition with similarities to IBD. Original story from La Trobe University La Trobe University researchers have identified a protein that is integral to gut health, providing an important lead in the search for a treatment for people with Inflammatory Bowel Disease (IBD). Research published in Communications Biology,...
by Anna Björklund, Identification of a conformational switch in c-MYC. a Overview of the MD strategy employed to identify regions that exhibit probe-induced conformational changes. b Normalized frequency distribution of Rg computed from the ensemble of structures generated from explicit solvent MD simulations in water (black) and water + benzene (red) for all nine c-MYC...
University of Sussex led research identifies protein (PANK4) as an obstacle that blocks cancer cells from responding to chemotherapeutic treatment for glioblastomaPeer-Reviewed Publication UNIVERSITY OF SUSSEX New research by the University of Sussex could help to increase life expectancy and improve treatment for an aggressive brain cancer, which impacts thousands of people every year in...
Scientists investigate how the Cpeb4 protein mediates the production of osteoclasts, which are involved in bone and joint diseases, including osteoporosis.Peer-Reviewed Publication TOKYO UNIVERSITY OF SCIENCE A RECENT STUDY BY TUS RESEARCHERS REVEAL THAT THE CPEB4 PROTEIN MAY HAVE A ROLE IN REGULATING OSTEOCLAST DIFFERENTIATION. THIS, IN TURN, COULD LEAD TO THE DEVELOPMENT OF NEW...
French musician Guilhem Gallart, a member of the Fonky Family, is seen here with his partner Wahiba; he was diagnosed with ALS in 2015. A new treatment shows promise against the deadly neurodegenerative disease ALS, a study based on mice showed Tuesday. Amyotrophic lateral sclerosis, sometimes called Lou Gehrig’s disease after the famous baseball player,...
