Study by Sharon Cantor and Jenna Whalen identifies novel vulnerability that may be a potential target for new therapeuticsPeer-Reviewed Publication UMass Chan Medical School FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Sharon Cantor, PhD, the Gladys Smith Martin Chair in Oncology and professor of molecular, cell and cancer biology at UMass Chan Medical Schoolview more Credit: Photo: UMass Chan Medical School Research by UMass...
Category: <span>Research Updates</span>
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Memory is impaired in aged rats after 3 days of high-fat eating
Study finds diet-related brain inflammation without metabolic changesPeer-Reviewed Publication Ohio State University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail COLUMBUS, Ohio – Just a few days of eating a diet high in saturated fat could be enough to cause memory problems and related brain inflammation in older adults, a new study in rats suggests. Researchers fed separate groups of young and...
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Clinical trial tests novel stem-cell treatment for Parkinson’s disease
Phase 1 trial reprograms patient’s own stem cells to replace dopamine neurons in the brainReports and Proceedings Mass General Brigham FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail A recently launched Phase 1 clinical trial at Mass General Brigham is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson’s disease in which a patient’s stem cells are reprogrammed to...
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Oral norovirus vaccine passes safety testing with a strong immune response in older adults
by Justin Jackson , Medical Xpress Oral immunization induces GI.1 VP1-specific circulating IgA ASC and up-regulates mucosal-homing integrins. Credit: Science Translational Medicine (2025). DOI: 10.1126/scitranslmed.ads0556 Researchers at Vaxart Inc. and the Center for Vaccine Development at the University of Maryland School of Medicine evaluated the safety and immunogenicity of an oral norovirus vaccine tablet, VXA-G1.1-NN. Results indicate...
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Alzheimer’s treatment may lie in the brain’s own cleanup crew: Harnessing microglia to clear plaques
by Northwestern University A spatial transcriptomics machine holds brain tissue samples in David Gate’s lab in Chicago. Credit: Northwestern University For more than three decades, scientists have been racing to stop Alzheimer’s disease by removing amyloid beta plaques—sticky clumps of toxic protein that accumulate in the brain. Now, a new Northwestern Medicine study suggests a promising...
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Aggressive breast cancer linked to obesity-driven diabetes
by Boston University School of Medicine Exosomes derived from IR adipocytes increase transcription of EMT genes and migration ability of 4T1 cells in vitro. Credit: Cancer Biology (2024). DOI: 10.1101/2024.05.01.592097; https://www.biorxiv.org/content/10.1101/2024.05.01.592097v1.full More than 120 million Americans suffer from diabetes or pre-diabetes. Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and TNBC patients with obesity-driven diabetes...
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Study reveals why scleroderma affects more women than men
by Hospital for Special Surgery Credit: Unsplash/CC0 Public Domain Two new studies led by researchers at Hospital for Special Surgery (HSS) have uncovered key biological mechanisms driving systemic sclerosis (SSc), or scleroderma—a rare and often devastating autoimmune disease that causes fibrosis (tissue hardening) and inflammation. The research, published in the March issue of the Journal of Experimental...
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Researchers identify a gene to guide novel therapeutics of nonalcoholic fatty liver diseases
by Elsevier Hepatocyte-specific Asah1 gene deletion aggravates Paigen diet (PD)–induced steatosis and injury in mice liver. Credit: The American Journal of Pathology (2024). DOI: 10.1016/j.ajpath.2024.11.003 Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid...
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Studies reveal new genetic roots of atrial fibrillation
by Leah Eisenstadt, Broad Institute of MIT and Harvard Credit: Susanna Hamilton, Broad Communications Two studies led by researchers at the Broad Institute of MIT and Harvard and Mass General Brigham have greatly expanded the number of known genetic variants that boost the risk for atrial fibrillation (AF), a common heart condition marked by an irregular...
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Two-Drug HIV Regimen Matches Three-Drug Options in Long-Term Treatment Success
Edited by Shreyasi Asthana January 14, 2025 022 Add to Email Alerts TOPLINE: Among treatment-naive people with HIV (PWH), dolutegravir/lamivudine demonstrates effectiveness comparable with those of the commonly prescribed three-drug regimens but offers better persistence and lower discontinuation rates at 96 weeks. METHODOLOGY: TAKEAWAY: IN PRACTICE: “These findings are consistent with the results of clinical...