Signalling from the sympathetic nervous system of mice when subjected to stress leads to the depletion of a stem-cell population in their hair follicles. This discovery sheds light on why stress turns hair prematurely grey. Shayla A. Clark & Christopher D. Deppmann It has been said that Marie Antoinette’s hair went completely white on the...
by Sarah C.p. Williams, University of California, Los Angeles UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have...
by Adam Dove, Carnegie Mellon University, Department of Chemical Engineering The incredible benefits of stem cell therapy have been widely known for decades. It can alleviate the pain of arthritis, and help patients heal exponentially faster after surgery. But stem cell therapies are prohibitively expensive—to the tune of $100,000 to $200,000 per patient. Because of...
As has been widely hyped for many years now, mesenchymal stem cells have the capacity to heal all sorts of damage in our bodies. The reality has been more complicated, since it is actually very difficult to get these cells to perform their magic just where we want them to. Damaged cartilage, for example, doesn’t...
A stem cell transplant — also called a bone marrow transplant — is a common treatment for blood cancers, such as acute myeloid leukemia (AML). Such treatment can cure blood cancers but also can lead to life-threatening complications, including heart problems and graft-versus-host disease, in which new immune cells from the donor attack a patient’s...
A clinical has begun trial testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis (MS). The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, will compare the safety, efficacy and cost-effectiveness of the two...
by Bentham Science Publishers The reconstitution of the blood system in humans holds great therapeutic potential to treat many disorders, like blood cancers, sickle-cell anemia and others. Successful reconstitution requires the transplantation and engraftment of hematopoietic (or blood) stem cells (HSCs), which after reaching their niche, start producing all types of blood cells, including platelets,...
Highlights • Sca1 + vascular stem cells produce new smooth muscle cells after severe vessel injury • A Sca1 +PDGFRa + subpopulation contributes to vascular repair and regeneration • Sca1-derived smooth muscle cells expand more than pre-existing smooth muscle • YAP is required for Sca1-derived smooth muscle cell expansion during vascular repair Summary Rapid regeneration...
UNIVERSITY OF HELSINKI A recently published study indicates that oral infections seem to have no association with the risk of stem cell transplantation patients dying of or getting a serious infection within six months of the procedure. A study collaboratively conducted by the University of Helsinki, the Helsinki University Hospital, the University of Basel and...
OSAKA UNIVERSITY A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis. Their research results were published in Stem Cell...
