Chenxia Hu & Lanjuan Li Stem Cell Research & Therapy volume 10, Article number: 307 (2019) Abstract Currently, the transplantation of mesenchymal stromal cells (MSCs) has emerged as an effective strategy to protect against tissue and organ injury. MSC transplantation also serves as a promising therapy for regenerative medicine, while poor engraftment and limited survival rates are major obstacles for...
Category: <span>Stem Cell Therapy</span>
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When added to gene therapy, plant-based compound may enable faster, more effective treatments
Scripps Research team finds that a nontoxic molecule closely related to resveratrol can overcome barriers to delivering gene therapy into stem cells. SCRIPPS RESEARCH INSTITUTE LA JOLLA, CA – Gene therapy has broadened the treatment possibilities for those with immune system deficiencies and blood-based conditions, such as sickle cell anemia and leukemia. These diseases, which...
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Stem cell studies offer hope for childhood neurological condition
by University of California, San Francisco Two new studies by an international team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age. Often diagnosed at birth with symptoms of weakness and breathing difficulties, the progressive neurological problems in PMD are caused...
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New mechanisms that regulate pluripotency in embryonic stem cells are discovered
by Karina Toledo, FAPESP Embryonic stem cells (ESCs) can give rise to many types of tissues and organs. At the turn of the century, these cells were believed to offer hope of treatment for several health problems, but as research advanced, scientists realized that understanding and controlling the behavior of ESCs would be a more...
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How time affects the fate of stem cells
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE How do temporal variations in protein concentrations affect biology? It’s a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes. In a new study published...
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Gene editing enables researchers to correct mutation in muscle stem cells in DMD model
by University of Missouri Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers at the University of Missouri School of Medicine have shown in a mouse study that the powerful gene editing technique known as CRISPR may provide the means for lifelong correction of the...
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Scientists find cause of debilitating eye disease
by Lowy Medical Research Institute Scientists at the Lowy Medical Research Institute (LMRI) have discovered one cause of a progressive, debilitating eye disease called macular telangiectasia type 2 (MacTel). The work, using genetic, clinical and biochemical studies has implications for other retinal eye diseases, as well as peripheral neuropathies. “This is a breakthrough not just for MacTel research, but for eye, neurological, and metabolic research...
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Woman is first to receive cornea made from ‘reprogrammed’ stem cells
The Japanese woman’s vision has improved since the transplant, say her doctors. At a press conference on 29 August, ophthalmologist Kohji Nishida from Osaka University, Japan, said the woman has a disease in which the stem cells that repair the cornea, a transparent layer that covers and protects the eye, are lost. The condition makes vision blurry and can lead to blindness....
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Rejuvenating brain stem cells may hold key to future MS treatments
By Catharine Paddock PhD Fact checked by Paula Field Scientists have found a way to make older brain stem cells in rats more youthful. The discovery could lead to improved treatments for aging-related diseases that degrade the brain and nervous system. The research concerns oligodendrocyte progenitor cells (OPCs), which are a type of stem cell,...
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Study links certain metabolites to stem cell function in the intestine
by Massachusetts Institute of Technology MIT biologists have discovered an unexpected effect of a ketogenic, or fat-rich, diet: They showed that high levels of ketone bodies, molecules produced by the breakdown of fat, help the intestine to maintain a large pool of adult stem cells, which are crucial for keeping the intestinal lining healthy. The...