Cardiff University researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future. The team, at the University’s European Cancer Stem Cell Research Institute, found they could stop gastric cells dividing and growing by deleting a particular cell-surface receptor implicated in the function of stem...
Category: <span>Stem Cell Therapy</span>
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Experimental Procedure Could Help Cure Sickle Cell Disease
Is gene therapy the answer to sickle cell disease? An experimental treatment that promises to correct the condition at the genetic level has already shown great promise in a clinical trial. Researchers reported that a patient who has gone through gene therapy to cure sickle cell disease no longer experiences symptoms and has an increased...
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Discovery points to innovative new way to treat Duchenne muscular dystrophy
Researchers at The Ottawa Hospital and the University of Ottawa have discovered a new way to treat the loss of muscle function caused by Duchenne muscular dystrophy in animal models of the disease. As reported in Cell Stem Cell, the team restored muscle stem cell function that is impaired in Duchenne muscular dystophy, resulting in...
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Researchers map previously unknown disease in children
Researchers correct genetic mutation that causes IPEX, a life–threatening autoimmune syndrome. Date:January 10, 2019Source:University of California – Los Angeles Health Sciences Summary:Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life–threatening autoimmune syndrome called IPEX. UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life–threatening autoimmune syndrome called IPEX. The gene therapy, which was tested in mice, is similar to the technique Kohn...
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Coaxing’ stem cells to form new bone tissue
New research has identified a possible way to manipulate certain stem cells to generate new bone tissue. The results of this investigation could vastly improve the outcome for people with skeletal injuries or conditions such as osteoporosis. Stem cells are undifferentiated cells that have the potential to specialize and undertake any function. Image: A new study looks at how to encourage stem cells to form new bone tissue rather than...
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Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics
Nocodazole can enrich cells in the G2/M, G1, and S phases of the cell cycle Treatment with nocodazole does not affect pluripotency maintenance hPSCs can efficiently form functional cell types after nocodazole treatment Nocodazole treatment allows genome-wide analyses of synchronous populations Summary Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these...
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New insight into the process of generation of new neurons in the adult brain
Researchers at Sahlgrenska Academy at the University of Gothenburg, Sweden, in collaboration with research groups in Finland, Canada, and Slovenia, have discovered a novel and unexpected function of nestin, the best known marker of neural stem cells. IMAGE: THE PICTURE SHOWS ASTROCYTES IN RED AND GREEN, THE AREAS WHERE INDIVIDUAL ASTROCYTES INTERCONNECT ARE YELLOW. A SINGLE...
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Stem cell shots linked to bacterial infection outbreak
Health officials on Thursday reported an outbreak of bacterial infections in people who got injections of stems cells derived from umbilical cord blood. In this Oct. 22, 2008 file photo, a researcher examines human embryonic stem cells with a microscope in Michigan. On Thursday, Dec. 20, 2018, the Centers for Disease Control and Prevention reported that at...
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Human blood cells can be directly reprogrammed into neural stem cells
Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central...
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Improved stem cell approach could aid fight against Parkinson’s
Scientists have taken a key step towards improving an emerging class of treatments for Parkinson’s disease. The advance could markedly improve a next generation of therapies for the condition, which affects around one in 350 people in the UK. It could aid development of the promising treatment – known as cell replacement therapy – which...