Discovery may improve ability to control the formation of mature cells from stem cell transplants UNIVERSITY OF CALIFORNIA – IRVINE Researchers from the University of California, Irvine have identified intrinsic cell properties that influence the fate of neural stem cells, affecting what type of brain cell they will form: neurons, astrocytes, or oligodendrocytes. This discovery...
Category: <span>Stem Cell Therapy</span>
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Stem cells show promise as drug delivery tool for childhood brain cancer
The latest in a series of laboratory breakthroughs could lead to a more effective way to treat the most common brain cancer in children. Scientists from the University of North Carolina Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, and the UNC School of Medicine reported results from early studies that demonstrate how cancer-hunting...
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Stem Cells from Baby Teeth Regenerate Dental Pulp after Implantation into Injured Teeth
Going to the dentist is usually not anyone’s idea of fun. In particular, root canals are no fun. However, if you have an abscessed tooth that hurts like the dickens, then a root canal may be your best bet for resuming normalcy. In younger patients, the innermost part of the tooth, the pulp, may die...
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Scalable and Efficient Bioprocess for Manufacturing Human Pluripotent Stem Cell-Derived Endothelial Cells
Highlights hPSCs can be differentiated into endothelial cells in 3D thermoreversible hydrogels The differentiation efficiency is similar to this in 2D cultures The global gene expression and phenotypes are similar to ECs made in 2D cultures Summary Endothelial cells (ECs) are of great value for cell therapy, tissue engineering, and drug discovery. Obtaining high-quantity and...
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New method grows brain cells from stem cells quickly and efficiently
Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells. Astrocytes play a significant role in neurodegenerative diseases. The new method reduces the time required to produce the cells from months to two weeks, and the study has been published in Nature Methods. “This means...
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The Rise of Direct Cell Reprogramming
There has been tremendous activity over the last decade in the development of stem cells therapeutics, which have relied on stem cell differentiation protocols, as well as techniques for direct cell reprogramming. Today, there are over 4,700 “stem cell” trials registered on ClinicalTrials.gov and publications have increased dramatically in recent years, demonstrating the rapidly growing interest of the scientific...
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Can Stem Cell Fillings Replace a Root Canal Procedure?
Those who live in fear of the infamous root canal – maligned worldwide for its painful nature and disliked for the fact that it kills the tooth – will find relief in the news that researchers have found a promising alternative in the form of stem cell fillings. This approach relies on treating root causes and conditions...
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This matrix delivers healing stem cells to injured elderly muscles
A car accident leaves an aging patient with severe muscle injuries that won’t heal. Treatment with muscle stem cells from a donor might restore damaged tissue, but doctors are unable to deliver them effectively. A new method may help change this. Hydrogel delivered stem cells called muscle satellite cells integrate in new muscle strands, green,...
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Tbx6 revealed as crucial to heart and skeleton formation from stem cells
Joint research with the University of Tsukuba shows Tbx6 is required for mesoderm formation and temporally controls cardiac/somite lineage diversification UNIVERSITY OF TSUKUBA Tsukuba, Japan – Many studies have attempted to identify a single transcription factor that can induce formation of mesoderm, an early layer in embryonic development, without help from other cellular proteins; none...
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Single transplantation of therapeutic macrophages improves rare lung disease in mice
Hereditary pulmonary alveolar proteinosis (herPAP) is a rare disease characterized by the slow build-up of lipo-protein material in the lungs due to the failure of highly specialized cells called macrophages, which usually eat away this material from the pulmonary air-space. On August 9 in the journal Stem Cell Reports, researchers in Germany demonstrate that a single...