Newly identified stem cells may hold key to regenerative therapies for lung disease IMAGE: UNIVERSITY OF IOWA RESEARCHERS HAVE IDENTIFIED A NEW POPULATION OF LUNG STEM CELLS THAT APPEAR TO BE IMPORTANT FOR REPAIRING THE AIRWAY FOLLOWING SEVERE INJURY. THE CELLS, WHICH RESIDE CREDIT: CELL STEM CELL The human airway is a system of branching tubes that connects...
Category: <span>Stem Cell Therapy</span>
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New discovery explains why cells with identical genes perform unique jobs
Scientists have made a significant discovery that explains how and why the billions of different cells in our bodies look and act so differently despite containing identical genes. The discovery, made by a team from the Smurfit Institute of Genetics at Trinity College Dublin, applies to all complex animals, including humans. The team has discovered...
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Mechanism vital to keeping blood stem cells functional uncovered
Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers. Now, a research team at Lund University in Sweden has uncovered a completely new mechanism that controls how proteins are produced...
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It’s all about the (stem cell) neighborhood
Stem cells have the ability to develop or differentiate, into the many different cell types in the body. They also serve as a repair system to replace aged or damaged cells. With their regenerative abilities, stem cells offer enormous potential in treating many diseases. Researchers at Duke-NUS Medical School have now identified how the stem...
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An index measures similarity between cancer cells and pluripotent stem cells
The new methodology measures tumor aggressiveness and the risk of relapse, helping doctors plan treatment, according to Brazilian scientists authors of a paper published in a special issue of the journal Cell The theory that cancer progression involves the acquisition by tumor cells of features similar to those of stem cells has gained strength in...
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A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells
Highlights Downregulation or inhibition of MCL-1 causes loss of OCT4 and NANOG expression MCL-1 downregulation or inhibition causes elongation of the mitochondrial network MCL-1 binds and modulates DRP-1 and OPA1 expression and activity Interactions between MCL-1 and DRP-1/OPA1 are disrupted by MCL-1 inhibitor Summary Human pluripotent stem cells (hPSCs) maintain a highly fragmented mitochondrial network, but the...
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Lab-grown heart tissue that mimics our own
A TOTAL ECLIPSE OF THE HEART CELLS. (KACEY RONALDSON-BOUCHARD AND GORDANA VUNJAK-NOVAKOVIC / COLUMBIA ENGINEERING) Columbia scientists have created a model of cardiac muscle that mimics the muscle found in adult hearts. Researchers turned stem cells into cardiac cells, then zapped them with electricity to make them contract as they developed. They increased the frequency...
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DNA methylation plays key role in stem cell differentiation
Neural progenitors cells differentiated from human embryonic stem cells. Northwestern Medicine scientists have discovered how the process of DNA methylation regulates the development of spinal cord motor neurons, according to a study published in the journal Cell Stem Cell. DNA methylation, an epigenetic mechanism that determines whether or not a gene is expressed, guides stem...
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How human embryonic stem cells sparked a revolution
After 20 years of hope, promise and controversy, human embryonic stem cells are reshaping biological concepts and starting to move into the clinic. Neural rosettes, derived from human embryonic stem cells, assemble into spheres in culture. Dieter Egli was just about to start graduate school in 1998 when researchers first worked out how to derive...
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New trials to repair Meniscal tears
A new treatment for meniscal tears based on stem cells has just been used for the first time on human subjects, with very promising results. This could help in treating thousands of sportsmen, by easing their recovery and reducing their sufferings. A Widespread Problem: Meniscal tears are one of the most common injuries that affect sportsmen,...