Patient narrates: One day in August last year I was reaching for food in the fridge, when I suddenly fell unconscious. I don’t know how long I was out for and I thought I had just tripped over.Afterwards I felt a bit dizzy, so I went for a lie down until my wife Catherine came...
Category: <span>Stem Cell Therapy</span>
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Synthetic Stem Cells Could Offer Therapeutic Benefits, Reduced Risks
Researchers from North Carolina State University, the University of North Carolina at Chapel Hill and First Affiliated Hospital of Zhengzhou University have developed a synthetic version of a cardiac stem cell. These synthetic stem cells offer therapeutic benefits comparable to those from natural stem cells and could reduce some of the risks associated with stem...
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Reproducing higher-order embryonic kidney structures using pluripotent stem cells
[LEFT] The higher-order structure of the kidney reconstructed from mouse ES cells (low magnification, green: collecting tube, red: nephron progenitor cells). [RIGHT] The nephron connected to the tip of the collecting tube (high …more In the embryonic kidney, three types of precursor cells interact to form three-dimensional structures of the kidney: nephron progenitor cells, ureteric...
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Can Young Stem Cells Make Older People Stronger?
Small trials using younger donors and elderly recipients hint that mesenchymal stem cell transfers might reduce frailty. Can one grow old without growing frail? One company is banking on the idea that with the right treatment, the answer can be ‘yes’ for many more people. In clinical trials published in October in the Journals of Gerontology, Longeveron, the firm...
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Crowding in the skin
IMAGE: SKIN CELLS GROWING IN A PETRI DISH (GREEN: CYTOSKELETON, RED: CELL-CELL JUNCTION PROTEIN) Human skin is a remarkable organ serving as a barrier protecting us from pathogens, toxic substances and others. Our skin needs to constantly renew throughout our lifetime as well as change its size to perfectly fit and cover the body. To...
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Researchers track muscle stem cell dynamics in response to injury and aging
SBP’s Alessandra Sacco, Ph.D., investigates how muscle stem cells become activated to repair damage, paving the way for stem cell-based therapies for muscle wasting and muscular dystrophy. A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) describes the biology behind why muscle stem cells respond differently to aging or...
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Reproducing higher-order embryonic kidney structures using pluripotent stem cells
[LEFT] The higher-order structure of the kidney reconstructed from mouse ES cells (low magnification, green: collecting tube, red: nephron progenitor cells). [RIGHT] The nephron connected to the tip of the collecting tube (high magnification, green: collecting tube, red: distal convoluted tubule, blue: proximal convoluted tubule, pink: glomus). In the embryonic kidney, three types of precursor...
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Researchers create skeletal muscle from stem cells
Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left). UCLA scientists have developed a new strategy to efficiently isolate, mature and transplant skeletal muscle cells created from human pluripotent stem cells, which can produce all cell types of the body....
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Study explores use of checkpoint inhibitors after relapse from donor stem cell transplant
Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one such agent – nivolumab – indicate that along with signs of effectiveness, it also produced significant side effects at...
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Inhibiting TOR boosts regenerative potential of adult tissues
Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Working in flies and mice, researchers at the Buck Institute and elsewhere discovered that TOR, a nutrient sensing pathway which is central to the aging process, drives...