A new method of harvesting stem cells for bone marrow transplantation – developed by a team of investigators from the Massachusetts General Hospital (MGH) Cancer Center and the Harvard Stem Cell Institute – appears to accomplish two goals: making the donation process more convenient and less unpleasant for donors and providing cells that are superior...
Category: <span>Stem Cell Therapy</span>
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Stem cells pave the way for new treatment of diabetes
415 million people worldwide have been diagnosed with diabetes. And the number continues to rise. Common to all diabetes patients is that they lack the ability to produce sufficient amounts of insulin, which regulates the blood sugar in the body. This can lead to a number of complications and in many cases be potentially fatal....
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Stem cells in intestinal lining may shed light on behavior of cancer cells
URBANA, Ill. – The lining of the intestines – the epithelium – does more than absorb nutrients from your lunch. It grows, shrinks, and adjusts the very makeup of its cells in response to whatever you just ate. And understanding that process might just give scientists new insights into the behavior of cancer cells. “We...
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Electrical Guidance of Human Stem Cells in the Rat Brain
Highlights Developed a technology and device delivering electric current to the brain in vivo Achieved stable delivery of currents to brain with monitoring and safety concerns Exhibited effective guidance of migration of transplanted human NSCs in live brain Demonstrated enhanced motility, survival, and differentiation of the guided hNSCs Summary Limited migration of neural stem cells in adult...
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The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery
Highlights CbpS436A increases the reprogramming efficiency of i-pericytes to NPCs in culture CbpS436A increases the number of locally derived NPCs from i-pericyte in vivo CbpS436A shows impaired vascular remodeling and functional recovery after stroke Summary Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since stroke-related brain damage...
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Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells
Highlights A GMP-compatible iPSC source has been generated from peripheral blood cells An industry-friendly protocol has been developed to produce NK cells from iPSCs These iPSC-derived NK cells are high-purity, functional, and KIR negative These iPSC-derived NK cells recognize and kill a wide variety of cancer cells Summary Current donor cell-dependent strategies can only produce...
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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease
Highlights PSEN1 mutant AD astrocytes manifest hallmarks of AD pathology Altered mitochondrial metabolism in AD astrocytes increases oxidative stress AD astrocytes reduce the calcium signaling activity of healthy neurons Astrocytes are important in the pathogenesis of AD Summary Alzheimer’s disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient...
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Scientists reverse diabetes in a mouse model using modified blood stem cells
In type 1 diabetes, autoreactive T-cells attack insulin-producing islet cells in the pancreas (frame 1). Fiorina and colleagues showed that the network of genetic regulatory factors controlling production of a protein called PD-L1 is …more Researchers at Boston Children’s Hospital have successfully reversed type 1 diabetes in a mouse model by infusing blood stem cells...
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Stem cells may offer hope for children with Hurler syndrome
Toshio Miki’s stem cell research may help children born with Hurler syndrome. A new therapy involving stem cells may offer a better quality of life for patients with Hurler syndrome, a rare genetic disease that can cause crippling physical conditions and lead to early death. In work with mice, Toshio Miki of the Keck...
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Researchers find lung stem cell, heal lung injury in mice
An image of an injured mouse lung partially regenerated by injected lung stem cells. The newly regenerated lung tissue is red, and the type-2 alveolar cells are green. Stanford scientists have found a cell that creates the two different compartments in the mouse lung. They hope their discovery could lead to better therapies for...