415 million people worldwide have been diagnosed with diabetes. And the number continues to rise. Common to all diabetes patients is that they lack the ability to produce sufficient amounts of insulin, which regulates the blood sugar in the body. This can lead to a number of complications and in many cases be potentially fatal....
Category: <span>Stem Cell Therapy</span>
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Inner ear stem cells may someday restore hearing
A stem cell-derived neuron grafted onto a mouse cochlea in the inner ear that lacked neurons. The new neuron is marked red, hair cells that convert sounds into neural signals are green, and hair bundles are blue. Want to restore hearing by injecting stem cells into the inner ear? Well, that can be a...
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Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
Highlights Spontaneous and S-phase-specific chromosome aberrations in differentiated cells Higher frequency of residual γ-H2AX foci after exposure to DNA-damaging agents Higher frequency of cells with 53BP1 and RIF1 co-localization in differentiated cells Higher frequency of cells with a reduced number of RAD51 or BRCA1 foci Summary The nitric oxide (NO)-cyclic GMP pathway contributes to human...
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The secrets of gecko tails could help heal human spine injuries
Geckos are able to regrow their tails by activating a group of stem cells when the tail is lost. Humans tend to think of themselves as the superior species. But the way we heal our bodies is extremely basic: We can (usually) mend our bones pretty well, but if we lose a limb or damage...
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Subset of stem cells identified as source for all cells in blood and immune systems
Researchers at Fred Hutchinson Cancer Research Center have identified a specific subset of adult blood stem cells that is exclusively responsible for repopulating the entire blood and immune system after a transplant. The discovery, to be published Nov. 1 in Science Translational Medicine, has the potential to revolutionize blood stem cell transplantation as well as the delivery and...
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Stem cells conduct cartilage regeneration but are not directly involved
Example picture: New double-transgenic rodent models identified the mode of action of stem cells. Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process. Researchers at the Vetmeduni Vienna have been able to resolve this issue...
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Transplanted Hematopoietic Stem Cells Reverse Damage Caused by Neuro-muscular Disorder
Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich’s ataxia (FA) measurably halted cellular damage caused by the degenerative disease. The findings, published online in the October 25 issue of Science Translational Medicine, suggest a potential...
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Chronic back pain stem cell treatment could cut need for opioids
Lower back pain affects around 28 million people in the US plainpicture A stem cell treatment could finally bring relief to millions of people with chronic lower back pain. If it works, the injection could become a crucial tool for curbing the opioid epidemic currently killing thousands in the US. Overdoses from prescription opioids have quadrupled since 1999,...
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Anti-aging stem cell treatment proves successful in early human trials
A landmark stem cell therapy to treat frailty in senior citizens is all set to move into the final phase of human clinical trials The results of two human clinical trials into a stem cell therapy that can reverse symptoms of age-associated frailty have been published, and the indications are that this landmark treatment...
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How skin cells learn to heal faster from inflammation
The stem cells (green) move into, and help heal, a wound faster when it has previously suffered a bout of inflammation New research has found that stem cells residing in the skin can learn from earlier inflammatory episodes and heal faster when subsequently injured. This insight suggests a newly discovered relationship between inflammation and...