Stem cells have been cultured to treat many different of conditions Lewis Houghton/Science Photo Library Last week, two people with type 1 diabetes became the first to receive implants containing cells generated from embryonic stem cells to treat their condition. The hope is that when blood sugar levels rise, the implants will release insulin to restore them...
Category: <span>Stem Cell Therapy</span>
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Clinical trials of stem cell-based “functional cure” for type 1 diabetes underway
A new treatment currently undergoing human clinical trials could see the end of pin prick tests for diabetics A human clinical trial examining the safety and efficacy of a “functional cure” for type 1 diabetes is currently underway. Trials of the novel islet cell replacement therapy developed by ViaCyte involve a device containing stem...
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Cardiac stem cells from young hearts could rejuvenate old hearts, new study shows
Animal study reveals that cardiosphere-derived cells secrete tiny vesicles that could ‘turn back the clock’ for age-related heart conditions LOS ANGELES (EMBARGOED UNTIL AUG. 14, 2017, AT 10 A.M. EDT ) – Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from...
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iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice
Highlights iPSC retina reconstructs outer nuclear layer in the end-stage retina Contacts between the host bipolar cells and graft photoreceptors were visualized rd1 mice became responsive to light after iPSC-retina transplantation RGC responses to light were recorded from host rd1 retina after transplantation Summary Recent success in functional recovery by photoreceptor precursor transplantation in dysfunctional retina has led...
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Scientists identify a new way to activate stem cells to make hair grow
UCLA researchers have discovered a new way to activate the stem cells in the hair follicle to make hair grow. The research, led by scientists Heather Christofk and William Lowry, may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss associated with such factors as...
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Amniotic sac in a dish: Stem cells form structures that may aid of infertility research
U-M cell biologists & engineers show how pluripotent stem cells self-organize into a structure similar to an early stage of human development ANN ARBOR, Mich. – The first few weeks after sperm meets egg still hold many mysteries. Among them: what causes the process to fail, leading to many cases of infertility. Despite the importance...
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Stem cell therapy for lung fibrosis conditions
A team of scientists from the UNC School of Medicine and North Carolina State University (NCSU) has developed promising research towards a possible stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis — often-fatal conditions that affect tens of millions of Americans. In...
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Concise Review: Stem Cells for Corneal Wound Healing
Abstract Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of...
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Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors
Highlights Tested CDM muscle differentiation protocol generates a heterogeneous population The population does not contribute to myofiber formation in vivo Regulated PAX7 expression allows expansion of homogeneous myogenic progenitors CDM iPAX7 myogenic progenitors are endowed with in vivo regenerative potential Summary Recent reports have documented the differentiation of human pluripotent stem cells toward the skeletal myogenic lineage...
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Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the...