Highlights Sumoylation regulates CD44 and MMP14 expression in basal breast and colon cancer SUMO inhibition clears cancer stem cells, repressing invasiveness and tumor growth Anacardic acid functions as a SUMO inhibitor to repress cancer stem cells TFAP2A mediates anti-tumor effects of SUMO inhibition in breast and colon cancers Summary Many solid cancers have an expanded...
Category: <span>Stem Cell Therapy</span>
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Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors
Highlights iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes Summary Early human embryonic stem cell (hESC)-derived neural populations consist of various embryonic neural progenitors (ENPs)...
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Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors
Highlights iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes Summary Early human embryonic stem cell (hESC)-derived neural populations consist of various embryonic neural progenitors (ENPs)...
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Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma
Highlights Temporal coding and noncoding transcriptomes during the muscle regenerative process Transcriptomes of satellite cells during activation, proliferation, differentiation Multidimensional chromatin maps of injured and noninjured muscle tissues Impact of epigenetic regulation and gene expression on muscle regeneration Summary Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote...
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Can deafness be cured using stem cells? Treatment that can allow people to hear again may be ready in 10 years
Stem cell treatment for deafness Researchers have grown healthy human ear hair cells using stem cells These could one day be used to replace faulty ear cells in deaf people Patients born deaf are currently treated with an artificial cochlear implant Scientists believe they are ‘on the brink’ of a cure for hereditary deafness using...