by Marla Paul, Northwestern University Strand of human hair at 200x magnification. Credit: Jan Homann/Wikipedia A newly discovered cause of balding in aging male mice could reveal a cause of hair loss in men and women as well, reports a study from Northwestern Medicine scientists. The findings provide new insight into how hair and tissues age....
By Gina Kolata By observing mouse hair follicles, scientists discovered an unexpected mechanism of aging. “If I didn’t see it with my own eyes I wouldn’t believe it,” one said. Researchers have found that hair loss from aging results from stem cells escaping hair follicles.Credit…Alamy Every person, every mouse, every dog, has one unmistakable sign of...
by University of Southampton Credit: CC0 Public Domain Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage. Cartilage acts as a shock absorber in joints, but it is susceptible to...
Researchers have found that old skeletal stem cells contribute to bone fragility and poor healing in mice, but that a stem cell-boosting gel may help restore function. Stanford Medicine researchers have discovered how genetic and molecular changes in aging skeletal stem cells may contribute to poor fracture healing, osteoporosis and various blood disorders, as well as general inflammation...
IMAGE: BASAL EPITHELIAL STEM CELLS (GREEN) CONTAINING THE PROTEIN IL-33 (RED) ARE VISIBLE IN A SAMPLE OF LUNG TISSUE (PICTURED). RESEARCHERS AT WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST. LOUIS HAVE FOUND THAT SUCH STEM CELLS MULTIPLY DURING AND AFTER A VIRAL RESPIRATORY INFECTION, SOMETIMES TRIGGERING A DETRIMENTAL REMODELING PROCESS THAT CAN CAUSE PERSISTENT LUNG...
IMAGE: TWENTY-SIX PATIENTS WITH XIAP DEFICIENCY UNDERWENT HCT BY THE END OF MARCH 2020, AND 22 (84.6%) SURVIVED. IBD IMPROVED REMARKABLY AFTER HCT. GUT MICROBIOTA INDICATED DYSBIOSIS BEFORE HCT; HOWEVER, IT WAS IMPROVED TO RESEMBLE THAT OF THE HEALTHY FAMILY MEMBERS AFTER HCT. THIS STUDY REVEALED THAT HCT HAS A FAVORABLE OUTCOME FOR XIAP DEFICIENCY....
IMAGE: MESENCHYMAL STROMAL CELLS (MSCS) ARE POTENT IMMUNOMODULATORS THAT HAVE SHOWN PROMISE IN TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). USING TRANSCRIPTOMICS, RESEARCHERS HAVE DEMONSTRATED THAT MSC INFUSIONS ELICIT A STRONG, YET TRANSIENT (<7 DAYS) TRANSCRIPTIONAL RESPONSE IN CIRCULATING MONONUCLEAR CELLS OF COPD PATIENTS, ATTENUATING KEY PRO-INFLAMMATORY PATHWAYS. THESE RESPONSES ARE LIKELY MEDIATED BY SOLUBLE FACTORS...
by University of Rochester Medical Center Fig. 1 Schematic of the Cas9 RNP delivery system. (A) Lipidoid nanoparticle (LNP)–encapsulated Cas9 RNP delivery system. PCL nanofibril (NF) that mimic the bone tissue environment were coated with mesenchymal stem cell membrane (MSCM) and were loaded with CXCL12α cytokine and LNP-coated Cas9 RNP. (B) The LNP-Cas9 RNP/MSCM-NF/CXCL12α complex can...
TOKYO METROPOLITAN UNIVERSITY IMAGE: (top) Intracellular localization of RUNX2 and YAP in MSCs on gelatin gels with different elastic moduli. Notice how more signal is seen in a single location (the nucleus) for stiffer substrates. (bottom) Illustration of how localization of YAP and RUNX2 changes with substrate stiffness for different batches. Note the consistency between...
UNIVERSITY OF ALABAMA AT BIRMINGHAM IMAGE: “THESE RESULTS SUGGEST THAT THE CYCLIN D2-CARDIOMYOCYTE TRANSPLANTATION MAY BE A POTENTIAL THERAPEUTIC STRATEGY FOR THE REPAIR OF INFARCTED HEARTS, ” SAID STUDY LEADER JIANYI “JAY ” ZHANG, M.D., PH.D., THE CHAIR OF BIOMEDICAL ENGINEERING, A JOINT DEPARTMENT OF THE UAB SCHOOL OF MEDICINE AND THE UAB SCHOOL OF ENGINEERING....
