Peer-Reviewed Publication First Hospital of Jilin University image: Functions of the gut microbiome. Created with BioRender.com. SCFA, short chain fatty acids.view more Credit: By Connor Prosty, Khaled Katergi, Jesse Papenburg, et al. The gut microbiome, an ecosystem of trillions of microorganisms in the human digestive tract, has been increasingly linked to chronic diseases. Research led by...
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Round Face’: A Viral Term’s Real Diagnostic Implications
Cortisol” has become a household word, popularized by social media and tagged in videos that garnered nearly 800 million views last year. This is linked to the also trending term “moon face,” which TikTok influencers and others have suggested is caused by high cortisol levels and, conversely, can be reduced through stress reduction. Although it’s true that cortisol is a...
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Signs and Symptoms of a Silent Heart Attack
A silent heart attack, also known as silent myocardial ischemia, is a heart attack with either no symptoms or minimal, unrecognizable symptoms. The presence of a silent heart attack is a strong predictor of mortality. Image Credit: Indypendenz/Shutterstock.com What is a silent heart attack? A silent heart attack is a condition of reduced blood flow...
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Retina implant shows promise in people with severe vision loss
Science Corporation Preliminary clinical trial data show that a retina implant restored vision for people whose central visual field has holes or blurry spots, Science Corporation reported this week. Trial participants could read text and recognize playing cards when using the implant, even though they were legally blind. The results, which have not been published in a...
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Mechanism of metabolic dysfunction-associated steatotic liver disease: Important role of lipid metabolism
Xia & He Publishing Inc. image: The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into saturated palmitic acid, which can be further modified into other fatty acids by enzymes such as SCD. De novo fatty...
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Artificial ‘nose’ can sniff out damaged fruit and spoiled meat
Norwegian University of Science and Technology image: Researchers at the Norwegian University of Science and Technology (NTNU) have created an antenna nose in a laboratory at the Gjøvik campus. Credit: Photo: Mads Wang-Svendsen Although smell has historically played an important role in the fight against diseases such as the plague and tuberculosis, the human nose is...
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For heavy drinkers, chronic pain associated with alcohol withdrawal could be permanent
Credit: Pharmacological Research (2024). DOI: 10.1016/j.phrs.2024.107462 One of the main physical symptoms of alcohol withdrawal is “allodynia”— increased sensitivity to mechanical stimuli that are normally innocuous, which is a clinical sign of chronic pain. In a new animal study published in Pharmacological Research, Scripps Research scientists show that the duration of this heightened sensitivity depends on the amount of alcohol...
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For people with Parkinson’s, moving is a mental challenge as well as a physical one
Distribution of participant scores on different tasks. (A) Index scores generated from mental chronometry of the box and blocks task are shown for the more affected versus less affected side. (B) Density plots represent distribution of index scores and our predictors of interest. Credit: Brain and Cognition (2024). DOI: 10.1016/j.bandc.2024.106181 It’s well known that Parkinson’s disease can...
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Topical JAK Inhibitor Shows Promise for Frontal Fibrosing Alopecia
AMSTERDAM — For frontal fibrosing alopecia (FFA), a disease with no approved therapies, topical delgocitinib attenuated inflammation and generated hair regrowth in women in a controlled phase 2a trial. “This is an exciting avenue for FFA if the data are recapitulated in a larger population. It could be an important new treatment option,” said Maryanne Senna, MD,...
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Metformin: An Unexpected Ally Against Long COVID?
Metformin use in adults with type 2 diabetes (T2D) is associated with a slightly lower incidence of long COVID and death within 180 days after SARS-CoV-2 infection. METHODOLOGY: TAKEAWAY: IN PRACTICE: “The incidence of PASC was lower when defined by [International Classification of Diseases] code compared with a computable phenotype in both databases,” the authors...