The circadian rhythms of the body’s biological clock may inform when you should start intermittent fasting, according to new research.

In recent years, diet trends such as intermittent fasting have popularized the practice of delayed or restricted eating for many people looking to manage caloric intake. Still, many open to restructuring their schedules have the same question: When is the right time to avoid eating?

“There are a lot of studies on both animals and humans that suggest it’s not only about how much you eat, but rather when you eat,” says lead author Carl Johnson, professor of biological sciences at Vanderbilt University.

“Our research looked to test the findings of existing fasting studies by asking real humans to participate in a multi-day test for two different meal time routines. What we found is that the body’s circadian rhythms regulate nighttime fat burning.”

For the study, Johnson and postgraduate student Kevin Kelly tested meal time restriction by monitoring the metabolism of middle-aged and older adults in a whole-room respiratory chamber, under controlled conditions, over two separate 56-hour sessions—both with the same overnight fasting period.

In the first set of tests, the researchers presented one of the three daily meals as breakfast whereas in the second session, the team presented food equal in nutrition to the same subjects as a late-evening snack.

They found that, while the two sessions did not differ in the amount of food eaten or the amount of physical activity of the participants, the daily timing of nutrient availability coupled with the body’s increased metabolism during sleep (thanks to the body’s circadian rhythms) flipped a switch on fat burning: In each instance, late-evening snacking delayed the body’s ability to target fat stores for energy and instead caused the body to target the readily accessible carbohydrates newly introduced into the body.

“The late-evening snack session resulted in less lipids oxidized than in the breakfast session,” says Kelly. “This confirms that the timing of meals during the daytime and nighttime cycle affects how ingested food is used versus stored, and that any food ingested prior to bedtime will delay the burning of fat during sleep.”

The study has important implications for eating habits, providing evidence contrary to a recent trend of skipping breakfast and suggesting instead a daily fast from supper to breakfast to help optimize weight management.

The study appears in PLOS Biology.

Funding for the project came from the National Institute of Neurological Disorders and Stroke and the National Institutes of Health.

Source: Vanderbilt University

Original Study DOI: 10.1371/journal.pbio.3000622