AML exposure to cytokines results in CART-123 exhaustion. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03271-5 In the clinical battle against leukemia, recent breakthroughs in chimeric antigen receptor T cells (CAR T) have given patients and doctors an unprecedented weapon. CAR T cell therapy has demonstrated efficacy in treating B-cell malignancies, achieving high response rates and durable remissions. However,...
Tag: <span>acute myeloid leukemias (AML)</span>
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Good vitamin D status can prevent cancer, improve prognosis of several cancers
A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment of colon cancer and blood cancers. In addition, high vitamin D responsiveness can be linked to a...
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Blocking cancer-specific mutations in leukemia and brain tumors
Candidate drug BAY1436032 (yellow) binds to the mutated enzyme IDH1. The substitution of a single amino acid in a metabolic enzyme can be the cause of various types of cancer. Scientists from the German Cancer Research Center and Heidelberg University Hospital, collaborating with Bayer AG, have now been able to develop a candidate for...