Peer-Reviewed Publication Vlaams Instituut voor Biotechnologie image: Motor neurons with damaged primary cilia (green) from patients with the C21orf2 mutationview more Credit: VIB Leuven, 20 December 2024- Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons. The average life span after diagnosis of this incurable disease is two to five years. In the relentless...
Tag: <span>ALS</span>
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Researchers develop personalized stem cell model ALS for fast, individualized drug testing
Peer-Reviewed Publication International Society for Stem Cell Research image: The technique for inducing differentiation of human motor neurons used in this paper clearly shows neuronal electrical activity.view more Credit: Satoru Morimoto Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years. In ALS, certain types of neurons called motor...
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Genetics suggest link between ALS and Parkinson’s disease
September 16, 2024 by Dennis Thompson People with rare genetic variants linked to degenerative brain disorders like Parkinson’s disease are at increased risk of developing ALS, a new study finds. Further, having these genetic variants increases the risk of a person having faster-progressing ALS (amyotrophic lateral sclerosis) and dying earlier, researchers found. The strongest link...
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Study finds genetic variant among people who experience a rare recovery from ALS
Credit: CC0 Public DomainThough it is exceedingly rare, some people diagnosed with amyotrophic lateral sclerosis (ALS) partially or fully recover from the lethal neurodegenerative disease. A better understanding of this baffling phenomenon, reported in medical literature for at least 60 years, could point to potential new treatment approaches. To that end, researchers at Duke Health...
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Junk Proteins” Associated With Cause of Aging and ALS Progression
Original story from CNIOAccumulation of “junk proteins”: normal cells (left) and cells subjected to the effect of the toxic arginine-rich protein (right). In the latter, ribosomal proteins (green fluorescent) and the size of nucleoli (red) are increased.Credit: CNIO. Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and...
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Recreational activities such as golfing, gardening may be associated with increased ALS risk among men
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Participation in recreational activities — including golfing, gardening or yard work, woodworking and hunting — may be associated with an increase in a person’s risk for developing amyotrophic lateral sclerosis, or ALS, a Michigan Medicine study finds. While many activities were associated with increased ALS risk, several were sex...
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New study identifies gene believed to be responsible for ALS and dementia
by Case Western Reserve University Representative human spinal cord tissue imaged at 4X objective for DAPI (blue), CD80 (red), and Iba1 (green) from an C9ORF72 ALS case and a non-ALS control. Scale bars represent 1000 µm or 100 µm as indicated. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adg7895Researchers at Case Western Reserve University School of Medicine...
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ALS: blocking inflammation to reduce symptoms
Peer-Reviewed Publication UNIVERSITÉ LAVAL Québec, January 10, 2024 – In people with amyotrophic lateral sclerosis (ALS), changes in neurons appear to activate immune cells. Lowering the inflammation could reduce the symptoms of the disease, according to a study led by Chantelle Sephton, a professor at Université Laval’s Faculty of Medicine. ALS is caused by the...
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ALS and frontotemporal dementia show origins in utero, according to new study
by Cristy Lytal, Keck School of Medicine of USC Grpahical abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112983 Even though neurodegenerative diseases often strike in middle age or later, patients could have structural differences in their brains that arise before birth. In a new study in Cell Reports, USC stem cell scientists used both patient-derived nerve cells and laboratory mice...
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Study raises possibility of immunotherapy treatment for ALS
OREGON HEALTH & SCIENCE UNIVERSITY New research reveals a type of monoclonal antibody already tested in certain forms of cancer may be a promising treatment in stopping the progression of amyotrophic lateral sclerosis, or ALS, a fatal neurodegenerative disease. The study, led by scientists at Oregon Health & Science University, published today in the Proceedings of the National...