by Kim North Shine, University of Michigan Credit: Andrea Piacquadio from Pexels Researchers from the University of Michigan have connected two blood biomarkers to changes in cognitive function in women in midlife, opening a potentially powerful path to noninvasive, earlier detection and interventions for Alzheimer’s disease and other dementias. The study analyzed two blood-based serum biomarkers,...
TOPLINE: Light therapy leads to significant improvement in several sleep measures and helps alleviate depression and agitation in patients with Alzheimer’s disease (AD), a meta-analysis of 15 high-quality trials shows.METHODOLOGY: TAKEAWAY: IN PRACTICE: “These findings, combined with its low side-effects, suggest the role of light therapy as a promising treatment for AD. Although light therapy...
by European Synchrotron Radiation Facility The structure of the ACAD9-ECSIT_CTER complex (ECSIT in red). An international team of researchers, led by the ESRF, have elucidated the structure of the ACAD9-ECSIT_CTER complex, by using cryo-EM techniques. This complex is important in the correct functioning of the energy-producing machinery in mitochondria. Credit: ESRF/M. Soler López. Credit: ESRF/M. Soler...
Credit: KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty Images When one member of a large Colombian family, plagued by Alzheimer’s disease for generations, evaded the disease (staying cognitively healthy into her 70s) despite inheriting the genetic mutation that caused her relatives to develop dementia in their 40s, researchers sought to understand why. The Colombian patient carried the presenilin-1...
by Washington University School of Medicine Credit: Cell (2023). DOI: 10.1016/j.cell.2023.11.029 Alzheimer’s disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop...
by Deb Balzer, Mayo Clinic Credit: Pixabay/CC0 Public Domain Alzheimer’s disease is a progressive neurologic disorder that causes memory loss and other cognitive decline due to brain cell degeneration. It’s the most common cause of dementia—a clinical syndrome characterized by a collection of symptoms that affect cognitive abilities, memory, thinking behavior. Dementia is not a specific...
Machine-learning approach detects Alzheimer’s disease with an accuracy of more than 90% — a potential boon for clinicians and scientists developing treatments. Max Kozlov AI that reads brain scans shows promise for finding Alzheimer’s genesMachine-learning approach detects Alzheimer’s disease with an accuracy of more than 90% — a potential boon for clinicians and scientists developing...
by Bill Hathaway, Yale University Credit: Pixabay/CC0 Public Domain An experimental drug can reduce the toxic changes in tau proteins known to damage neurons in brains with Alzheimer’s disease, researchers from Yale School of Medicine and Johns Hopkins University report. While much research related to Alzheimer’s disease has concentrated on identifying ways to reduce the buildup...
Megan Brooks November 02, 2023 An investigational natural killer cell (NK) therapy has shown promise in the treatment of Alzheimer’s disease (AD), in a small phase 1 proof-of-concept clinical trial. SNK01, being developed by NKGen Biotech, is an autologous, nongenetically modified NK cell product that has enhanced cytotoxicity and activating receptor expression. “When we give these enhanced...
by Robert Langreth and Gerry Smith, Bloomberg News Credit: Unsplash/CC0 Public DomainAn experimental version of Eisai Co’s Alzheimer’s drug that might be given in patients’ homes exceeded the power of Leqembi, its approved infused formulation, in an early study that could pave the way to bolstering uptake. After six months of treatment, an injected form...
