by National University of Singapore Credit: Karolina Grabowska from Pexels A study in Alzheimer’s & Dementia has demonstrated the high accuracy of plasma p-tau217 as a blood-based biomarker for detecting abnormal brain beta-amyloid (Aβ) pathology, a hallmark of Alzheimer’s disease (AD). More significantly, the study validates its effectiveness even in individuals with cerebrovascular disease (CeVD), which is highly...
Tag: <span>Alzheimer’s disease</span>
Post
Anti-amyloid drug shows signs of preventing Alzheimer’s dementia
by Washington University in St. Louis Randall J. Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at WashU Medicine, is the study director of an international clinical trial that finds an anti-amyloid drug can delay the onset of cognitive decline if given many years before symptoms of Alzheimer’s disease arise. The participants...
Post
Latest Alzheimer’s drug shown less effective in females than males
by McGill University Credit: Unsplash/CC0 Public Domain Since becoming only the second Alzheimer’s-modifying drug to gain American Federal Drug Administration approval in 2023, sales of lecanemab, known by its brand name Leqembi, have risen steadily, reaching $87 million USD in the last quarter of 2024. In its Phase 3 clinical trial, lecanemab slowed cognitive decline by 27% overall,...
Post
Promising peptide compound can decrease appetite and protect the brain against Alzheimer’s-type diseases
by Institute of Organic Chemistry and Biochemistry of the CAS Modified peptide derived from the natural CART peptide. After repeated administration to mice suffering from obesity and prediabetes, the mice began to eat less, lost weight, and their metabolism improved. Their brains showed reduced Tau protein pathology, and new nerve cells also began to form in...
Post
IL-12 targeting could open pathways for new Alzheimer’s treatments
Reviewed Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationMar 17 2025 Researchers from Charité – Universitätsmedizin Berlin and the Max Delbrück Center have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer’s disease. The study was published in in the journal “Nature Aging.” Microglia, the brain’s immune cells, usually...
Post
Inflammatory messenger fuels Alzheimer’s
Researchers from Charité – Universitätsmedizin Berlin and the Max Delbrück Center have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer’s disease.Peer-Reviewed Publication Max Delbrück Center for Molecular Medicine in the Helmholtz Association FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Co-cultures consisting of neurons that form nerve fibers (pink) and oligodendrocytes that coat these nerve...
Post
EYE CHANGES MAY BE EARLY WARNING FOR ALZHEIMER’S
MARCH 11TH, 2025POSTED BY RORY APPLETON – INDIANA U. (Credit: Getty Images) SHARE THIS ARTICLE You are free to share this article under the Attribution 4.0 International license. TAGS UNIVERSITY INDIANA UNIVERSITY Researchers have identified that an eye condition affecting the retina, the light-sensing tissue in the back of the eye, may serve as an early indicator for...
Post
Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer’s disease
by The Scripps Research Institute Microscopy images show fluorescently stained mouse brains expressing genes that cause Alzheimer’s disease. Compared with an Alzheimer’s-like brain (left), the more intense green color (right) indicates more neuronal synapses—connections between nerve cells that underlie learning and memory—upon treatment with the drug diAcCA. Credit: Scripps Research The herb rosemary has long been...
Post
Curing Alzheimer’s disease: Magic bullet or magic shotgun blast?
by Donald Weaver, The Conversation Credit: Pixabay/CC0 Public Domain Why are researchers still fumbling in the quest to cure what is arguably one of the most important diseases confronting humankind—Alzheimer’s disease? Despite decades of research, there is still no curative treatment for Alzheimer’s—no “magic bullet” that stops this devastating degenerative brain disease in its tracks. Not surprisingly, finding...
Post
Hormone therapy among older women linked to tau accumulation, a hallmark of Alzheimer’s disease
by Mass General Brigham HT interaction with age to predict the neocortical Aβ accumulation in cognitively unimpaired females. Neocortical PiB DVRs are shown. Baseline age was entered as a continuous variable and categorized for visualization. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adt1288 A new study by Mass General Brigham researchers has found faster accumulation of tau—a key indicator of...