Tag: <span>Alzheimer’s disease</span>

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Alzheimer’s brain inflammation: Immune cells react differently to amyloid-beta, research suggests

by Biophysical Society Myddosome formation (shown in yellow-green) is triggered by Aβ aggregates (shown in red) in macrophages. Credit: Arpan Dey. Brain inflammation, while a crucial part of the body’s immune response, takes on a detrimental role in Alzheimer’s disease. Unlike the acute, short-lived inflammation that combats infection, the inflammation associated with Alzheimer’s becomes chronic and...

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Next-gen Alzheimer’s drugs extend independent living by months

by Washington University in St. Louis Credit: Unsplash/CC0 Public Domain In the past two years, the Food and Drug Administration has approved two novel Alzheimer’s therapies, based on data from clinical trials showing that both drugs slowed the progression of the disease. But while the approvals of lecanemab and donanemab, both antibody therapies that clear plaque-causing...

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How a former navy mechanic defied the genetic odds of inherited Alzheimer’s disease

by Justin Jackson , Medical Xpress Schematic representation of the pedigree for the DIAN family carriers of the pathogenic mutation PSEN2 p.Asn141Ile. Credit: Nature Medicine (2025). DOI: 10.1038/s41591-025-03494-0 Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant known...

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Lab-designed chimeric protein shows beneficial effects in animal models of Alzheimer’s disease

by Autonomous University of Barcelona Credit: Autonomous University of Barcelona A research team at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has developed a new protein capable of improving memory and reducing tau protein levels in animal models of Alzheimer’s disease. The new compound—HEBE, generated by fusing three proteins—represents a new approach...

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Cerebrospinal biomarker test can detect Alzheimer’s pathology earlier, study shows

by University of Pittsburgh Credit: Unsplash/CC0 Public Domain Years before tau tangles show up in brain scans of patients with Alzheimer’s disease, a biomarker test developed at the University of Pittsburgh School of Medicine can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal fluid and potentially...

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New work proposes a unifying model of Alzheimer’s disease: Large-scale alterations to gene expression

by Richard Harth, Arizona State University Stress granules are transient structures that assemble in response to cellular stress, temporarily halting nonessential processes to aid cell recovery. Under normal conditions, they protect the cell and dissipate once the stress is resolved. However, in Alzheimer’s disease, stress granules persist abnormally, becoming chronic and pathological. They trap essential molecules...

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The two proteins involved in Alzheimer’s disease affect brain circuits differently, study shows

by Autonomous University of Barcelona Image of neurons of the hippocampus that regulates memory are affected by Alzheimer’s disease pathology in the mouse model generated in the study. Credit: Autonomous University of Barcelona A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the two key pathological hallmarks...

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Hannah Richardson, 24, has signed up for a clinical trial that will try to prevent Alzheimer’s disease (Huy Mach/WashU Medicine)  February 4, 2025 09:00 AM EST R&D

New study will try to stop Alzheimer’s decades before it begins, using experimental Eli Lilly drugRyan CrossSenior Science CorrespondentAlzheimer’s disease has afflicted Hannah Richardson’s family for generations. A rare genetic mutation, passed down from her great-grandmother, has struck her relatives with the first signs of memory loss at an average age of 39. Last year,...

February 4, 2025February 4, 2025by In News
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A neurovascular approach to detecting Alzheimer’s disease

by Lancaster University Researchers combined non-invasive measurements of brain blood flow and electrical activity with novel analysis methods developed by Lancaster University’s Nonlinear and Biomedical Physics group. Credit: Jill Jennings Research led by Lancaster University has revealed clear evidence that changes in the orchestration of brain oxygenation dynamics and neuronal function in Alzheimer’s disease contribute to...

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Alzheimer’s disease linked to disrupted brain oxygenation and neuronal function

 Reviewed Lancaster UniversityFeb 3 2025 Research led by Lancaster University has revealed clear evidence that changes in the orchestration of brain oxygenation dynamics and neuronal function in Alzheimer’s disease contribute to the neurodegeneration. The study “Neurovascular phase coherence is altered in Alzheimer’s Disease” is published in Brain Communications. The lead author is Aneta Stefanovska with Juliane...