by Vanderbilt University Credit: ACS Chemical Neuroscience (2024). DOI: 10.1021/acschemneuro.4c00769 Researchers at the Warren Center for Neuroscience Drug Discovery, a clinical stage biotech within the Vanderbilt University School of Medicine Basic Sciences, have detailed the successful drug discovery of a phase I single ascending dose clinical trial of VU319, a drug for memory loss in people with Alzheimer’s...
Tag: <span>Alzheimer’s disease</span>
Post
How to keep life engaging for people with Alzheimer’s
by Greg Jicha, University of Kentucky Credit: Unsplash/CC0 Public Domain Adapting activities for individuals with Alzheimer’s disease is essential for maintaining their engagement and well-being. As Alzheimer’s progresses, activities that were once routine can become challenging. Here’s how caregivers can help loved ones enjoy meaningful and fulfilling experiences. Make activities accessible Choose tasks that align with...
Post
X-chromosome study reveals hidden genetic links to Alzheimer’s disease
By Hugo Francisco de SouzaReviewed by Susha Cheriyedath, M.Sc.Dec 9 2024 Despite decades of research, the X-chromosome’s impact on Alzheimer’s was largely ignored until now. Explore how seven newly discovered genetic loci could revolutionize our understanding of the disease. Study: X‐chromosome-wide association study for Alzheimer’s disease. Image Credit: nobeastsofierce / Shutterstock Conventional investigations of the genetic contributors to Alzheimer’s disease...
Post
Portable MRI shows promise for expanding brain imaging for Alzheimer’s disease
By leveraging machine learning tools, Mass General Brigham researchers measured markers of Alzheimer’s disease on portable MRI with accuracy matching that of standard MRIPeer-Reviewed Publication Massachusetts General Hospital Globally, approximately 139 million people are expected to have Alzheimer’s disease (AD) by 2050. Magnetic resonance imaging (MRI) is an important tool for identifying changes in brain...
Post
Sex differences in neuron protection could reveal Alzheimer’s target
by Jim Schnabel, Cornell University Biological sex modulates responses to demyelination with age or disease pathology through Tlr7. Credit: Science (2024). DOI: 10.1126/science.adk7844 Inhibiting TLR7, an immune signaling protein, may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer’s disease and ordinary aging, suggests a study led by researchers at Weill Cornell Medicine....
Post
Novel all-in-one computational pipeline offers insights into Alzheimer’s mechanisms and potential drug targets
by Columbia University’s Mailman School of Public Health Credit: Pixabay/CC0 Public Domain Researchers at Columbia University Mailman School of Public Health have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including Alzheimer’s disease (AD). This innovative tool analyzes biomarkers that can induce 3D structural changes in proteins, providing critical insights...
Post
Hidden fat may predict Alzheimer’s 20 years ahead of symptoms
by Radiological Society of North America Comparison of cerebral blood flow in 65 cognitively normal midlife individuals showed that individuals with obesity and high visceral adipose tissue have reduced blood flow in the temporal and parietal regions of the brain. Credit: Radiological Society of North America (RSNA) and Mahsa Dolatshahi, M.D., M.P.H. Researchers have linked a...
Post
Disruption of mechanical signaling in brain could be basis for development of Alzheimer’s disease, study proposes
by University of Liverpool A concept model of mechano-homeostasis and dyshomeostasis leading to whole-scale synaptic changes. Credit: Open Biology (2024). DOI: 10.1098/rsob.240185 A new study from the University of Liverpool represents a significant step forward in scientists’ understanding of Alzheimer’s disease. Researchers have shed new light on how mechanical signaling in the brain is disrupted and could lead...
Post
Nasal spray drug shows promise in Alzheimer’s research
by Catholic University of the Sacred Heart PET scan of a human brain with Alzheimer’s disease. Credit: public domain A future treatment for Alzheimer disease may involve a nasal spray. Researchers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS have discovered that by inhibiting the brain enzyme S-acyltransferase (zDHHC) through a nasal-spray drug, they...
Post
New schizophrenia drug could treat Alzheimer’s disease
Half a dozen drugs are in trials for conditions of the brain, but success is not guaranteed. Medicines for schizophrenia are being investigated to treat other brain disorders.Credit: K H Fung/Science Photo Library Since a schizophrenia drug, the first in decades with an innovative mechanism of action, gained US regulatory approval in September, some researchers have...