by University of Tsukuba Credit: Sergey Nivens/Shutterstock Alzheimer’s disease (AD) is the most common form of dementia. It is important to start intervention from an early stage, e.g., the mild cognitive impairment (MCI) stage, to prevent or delay the progression of AD. For the early detection of AD and MCI, there is a growing need to...
Cima University of Navarra researchers show that smelling this substance modulates the immune system and improves cognition in animals with this neurodegenerative disease. This study opens the door to developing therapies based on stimulating and traini UNIVERSIDAD DE NAVARRA IMAGE: FROM LEFT TO RIGHT: CIMA UNIVERSITY OF NAVARRA RESEARCHERS MARÍA ALFARO, MARÍA ESPELOSÍN, MAR CUADRADO,...
by University College London Effect of MAPTRx on CSF concentrations of p-tau protein and tau/Aβ42. a, The mean percentage change from baseline in p-tau over time according to dose group. b, The mean percentage change from baseline in the ratio of t-tau to Aβ42 over time according to dose group. Error bars indicate the standard error of...
by Columbia University Receiver Operator Curve Analyses of Plasma Biomarker Performance in Classifying Cerebrospinal Fluid (CSF)–Supported Diagnosis of Alzheimer Disease Performance of plasma biomarkers amyloid-β 1-40 (Aβ40) (inverse), amyloid-β 1-42 (Aβ42) (inverse), total tau (T-tau), neurofilament light chain (NfL), phosphorylated tau181 (P-tau181), and ratios of Aβ40/Aβ42, T-tau/Aβ42, and P-tau181/Aβ42 in classifying CSF biomarker (P-tau181/Aβ42)–supported diagnosis of...
by Institute for Basic Science Fig. 1. Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acetate uptake in primary cultured astrocytes. B. Blockade effect of MCT1 gene-silencing on 14C-acetate uptake in primary cultured astrocytes. C. Representative images displaying GFAP and MCT1 expressions in primary...
by Karolinska Institutet Credit: CC0 Public Domain Alzheimer’s disease begins decades before the onset of any symptoms, such as memory loss. Consequently, early diagnosis increases the chances of slowing the disease down with drugs. A new study on an inherited form of the disease shows that a protein called GFAP is a possible biomarker for very...
by Mass General Brigham Credit: Pixabay/CC0 Public Domain Women are more likely than men to develop Alzheimer’s disease (AD), with women making up two-thirds of the population living with AD. A new study, led by Mass General Brigham researchers, sheds light on the relationship between the risk of Alzheimer’s disease and age of menopause and use...
TOPICS: Alzheimer’s Brain Cedars-Sinai Medical Center Eyes By CEDARS-SINAI MEDICAL CENTER MARCH 26, 2023 Researchers at Cedars-Sinai have conducted the most comprehensive analysis of retinal changes in Alzheimer’s disease patients and their correlation with brain and cognitive changes. Published in the journal Acta Neuropathologica, this study is crucial for understanding the intricate effects of Alzheimer’s on the retina,...
MARY ANN LIEBERT, INC./GENETIC ENGINEERING NEWS IMAGE: FOCUSES ON THE LATEST ADVANCES IN THE CLINICAL AND LABORATORY INVESTIGATION OF TRAUMATIC BRAIN AND SPINAL CORD INJURY. EMPHASIS IS ON THE BASIC PATHOBIOLOGY OF INJURY TO THE NERVOUS SYSTEM, AND THE PAPERS AND REVIEWS EVALUATE PRECLINICAL AND CLINICAL TRIALS TARGETED AT IMPROVING THE EARLY MANAGEMENT AND LONG-TERM...
In a recent article published in Experimental Gerontology, researchers systematically reviewed English language publications from 13 electronic databases, such as PubMed/Medline, Google Scholar, and Web of Science. Study: A systematic review of exercise modalities that reduce pro-inflammatory cytokines in humans and animals’ models with mild cognitive impairment or dementia. Image Credit: StockLite/Shutterstock They investigated which exercises might...
