by Sahmyook University Researchers from Korea have now identified phyllodulcin, a major component of hydrangeas, as a potential candidate for the treatment of Alzheimer’s disease. In this animal model study, phyllodulcin controlled the formation and degradation of amyloid aggregates, thereby targeting the main cause of AD. It also reduced memory impairment and improved memory formation processes...
by Perelman School of Medicine at the University of Pennsylvania Individuals with Alzheimer’s disease (AD) have increased neurofibrillary tangles (NFTs) of tau proteins but reduced TRIM11, as shown in the bottom two quadrants, compared to individuals without AD, shown in the top two quadrants. Credit: Penn Medicine A gene encoding a protein linked to tau production—tripartite...
by Justin Jackson, Medical Xpress Credit: Pixabay/CC0 Public Domain Researchers at Washington University School of Medicine in St. Louis have identified proteomic changes associated with forms of Alzheimer’s disease (AD). In a paper, “Proteomics of brain, CSF, and blood identifies molecular signatures for distinguishing sporadic and genetic Alzheimer’s disease,” published in Science Translational Medicine, the...
by Autonomous University of Barcelona A research team from the Universitat Autònoma de Barcelona (UAB) has studied the livers of Alzheimer’s disease mice models and described morphological, cellular, and functional alterations. In addition, they demonstrated the importance of the liver-brain axis regarding the psychological symptoms of the disease. Traditionally, research in Alzheimer’s disease has focused exclusively...
INTERNATIONAL SOCIETY FOR STEM CELL RESEARCH IMAGE: HUMAN 3D CORTICAL SPHEROID WITH A PSEN1 MUTATION. CREDIT: ERIN HURLEY, UNIVERSITY OF TEXAS AT SAN ANTONIO Alzheimer’s disease (AD) mainly affects the older population. Recent research found early disease signs in cell culture models of early human brain development, raising the possibility that the disease has its origins much earlier...
by King’s College London Attenuated inflammatory arthritis pain in TASTPM is caused by microglia that are insensitive to Gal-3. a Illustration of the superficial laminae of the dorsal horn of the spinal cord, where nociceptor terminals synapse on laminae I projection neurons. b In homoeostasis, microglia constantly survey the parenchyma by responding to cues in their microenvironment. c During inflammatory arthritis, TLR4+ P2Y12+ microglia...
Carla Nieto Martínez June 15, 2023 MADRID — Recent research has confirmed the impact of periodontitis on risk of neurologic diseases, especially the increased risks for stroke and Alzheimer’s disease. The Spanish Society of Dentistry and Osseointegration (SEPA) and the Spanish Society of Neurology (SEN) recently released a report with the latest data on this topic. The report reviews, updates,...
by Netherlands Institute for Neuroscience – KNAW Increase in microRNA-132 causes microglia to transition from an activated disease-associated state to a more balanced homeostatic state. The exact implications of this will need to be determined through further research. Credit: Netherlands Institute for Neuroscience A new study from the Netherlands Institute for Neuroscience and the VIB-KU Leuven...
IOS PRESS IMAGE: THE MOST STRIKING FINDINGS WERE THE MONONUCLEAR ATTACK ON CEREBRAL AMYLOID ANGIOPATHY (HISTIOCYTIC VASCULITIS) WITH FIBRINOID NECROSIS (LEFT, AΒ IMMUNOHISTOCHEMISTRY [4G8]), AND FOCALLY PRONOUNCED AΒ PLAQUE PHAGOCYTOSIS (RIGHT, CD163 IMMUNOHISTOCHEMISTRY), THE COMBINATION OF WHICH DOES NOT OTHERWISE EXIST IN NATURE. CREDIT: JOURNAL OF ALZHEIMER’S DISEASE. Amsterdam, May 24, 2023 – In a noteworthy case...
by Atrium Health Wake Forest Baptist Credit: JCI Insight (2023). DOI: 10.1172/jci.insight.162454 It’s well-known that people with type 2 diabetes are at an increased risk of developing Alzheimer’s disease, but the reason why isn’t fully understood and is an area of current research. Now, scientists at Wake Forest University School of Medicine have uncovered a novel mechanism...
