by Northwestern University A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ WikipediaAlzheimer’s disease, which is expected to have affected about 6.7 million patients in the U.S. in 2023, results in a substantial...
Subtypes differed in abnormal proteins, disease progression and life expectancyBy JOHN ELY SENIOR HEALTH REPORTER FOR MAILONLINE Scientists have discovered there are five types of Alzheimer’s, and this may explain why some drugs appear to be ineffective against the condition. Dutch experts came to this conclusion after examining proteins in the cerebrospinal fluid, found in...
by Amsterdam University Medical Center Credit: Pixabay/CC0 Public DomainDutch scientists have discovered five biological variants of Alzheimer’s disease, which may require different treatments. As a result, previously tested drugs may incorrectly appear to be ineffective or only minimally effective. This is the conclusion of researcher Betty Tijms and colleagues from Alzheimer Center Amsterdam, Amsterdam UMC...
by Josh Barney, University of Virginia Tau proteins are prime suspects in Alzheimer’s and other neurodegenerative disorders. New UVA research could open doors to future treatments. Credit: Emily Faith Morgan / University of Virginia Communications Alzheimer’s disease researchers at the University of Virginia have discovered how harmful tau proteins damage the essential operating instructions for our...
by Karolinska Institutet Credit: CC0 Public Domain Statins could slow the progression of Alzheimer’s disease, at least for some patients. This is the result of a new study led by Karolinska Institutet published in Alzheimer Research and Therapy. But the researchers are cautious in their interpretations and see the results as a first step in a...
Researchers from Charité and McGill University quantify association between Helicobacter pylori and Alzheimer’s diseasePeer-Reviewed Publication CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN Infection with the stomach bacterium Helicobacter pylori could increase the risk of developing Alzheimer’s disease: In people over the age of 50, the risk following a symptomatic infection can be an average of 11 percent higher,...
Some researchers hoping that gene-editing technology can conquer forms of Alzheimer’s caused by genetic mutations. Tosin Thompson A laboratory-grown cell that produces amyloid precursor protein. Such cells are cultured for use in Alzheimer’s research.Credit: Simon Fraser/Science Photo Library Last month saw the first-ever approval of a gene therapy that uses the CRISPR–Cas9 gene-editing tool, a...
by Hong Kong Baptist University Development and characterization of Fe65-engineered exosomes. a Schematic diagram showing the steps involved in the production of engineered Fe65-EXO. Representative b, c immunofluorescence images showing expression of Fe65, d protein level of Fe65 in control- and Fe65 OE- HT22 hippocampus neuron cells. Representative e–g size distribution, h–j, k–m CD63-, and Fe65-positive...
by Washington University School of Medicine Lipid deposits (green) in brain immune cells (red) from mice with Alzheimer’s-like disease all but disappear (right) after the mice are treated with an experimental drug. Researchers at Washington University School of Medicine in St. Louis have found that a form of cholesterol known as cholesteryl esters builds up in...
by Radiological Society of North America Increased neuroinflammation (yellow colors) associated with higher hidden fat (visceral fat) in the cohort of 54 participants with an average age of 50 years in the brain’s white matter. The green colors are the normal white matter. Credit: RSNA/Mahsa Dolatshahi, M.D., M.P.H. Higher amounts of visceral abdominal fat in midlife...
