by Hong Kong Baptist University Development and characterization of Fe65-engineered exosomes. a Schematic diagram showing the steps involved in the production of engineered Fe65-EXO. Representative b, c immunofluorescence images showing expression of Fe65, d protein level of Fe65 in control- and Fe65 OE- HT22 hippocampus neuron cells. Representative e–g size distribution, h–j, k–m CD63-, and Fe65-positive...
by Washington University School of Medicine Lipid deposits (green) in brain immune cells (red) from mice with Alzheimer’s-like disease all but disappear (right) after the mice are treated with an experimental drug. Researchers at Washington University School of Medicine in St. Louis have found that a form of cholesterol known as cholesteryl esters builds up in...
by Radiological Society of North America Increased neuroinflammation (yellow colors) associated with higher hidden fat (visceral fat) in the cohort of 54 participants with an average age of 50 years in the brain’s white matter. The green colors are the normal white matter. Credit: RSNA/Mahsa Dolatshahi, M.D., M.P.H. Higher amounts of visceral abdominal fat in midlife...
by Gladstone Institutes New research, led by a Gladstone team including Maxine Nelson (left) and Yadong Huang (right), sheds light on protective mechanisms of the “Christchurch mutation.” Credit: Michael Short/Gladstone Institutes (2023) Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the...
by Karolinska Institutet Credit: CC0 Public Domain An early phase in the process of developing Alzheimer’s disease is a metabolic increase in a part of the brain called the hippocampus, report researchers from Karolinska Institutet in a study published in Molecular Psychiatry. The discovery opens up for new potential methods of early intervention. Alzheimer’s disease is...
by Jara Pérez Jiménez, Cara Frankenfeld, Léopold L Fezeu Kamedjie, Margaret Slavin and Valentina A. Andreeva, The Conversation Credit: CC0 Public DomainPerhaps the word “polyphenol” means little to you, but they certainly mean a lot to your health. Polyphenols are a family of chemical compounds present in foods of vegetable origin and seaweed that have been...
Some studies have shown that vaccinated individuals appear less likely than the unvaccinated to develop dementia, although scientists aren’t sure why By Marlene Cimons – Washington PostOctober 25, 2023 at 7:00 a.m. EDT There are many good reasons to get a flu shot this fall, but here’s one that might surprise you: It could protect...
A study in mice and cell cultures suggests that Candida albicans can infect the brain and trigger Alzheimer’s-like mechanisms. Image credit: Paul Campbell/Getty Images.Researchers have uncovered how a common fungus enters the brain and generates toxic proteins implicated in Alzheimer’s disease.By studying animal models, the team found that the fungus Candida albicans uses enzymes to...
By REBECCA DYER A false-color scanning electron microscope image of a fibrin blood clot before and after the buildup of protofibrils. (Anurag Sharma/Pradeep Singh)Lecanemab received FDA approval in January after a phase 3 trial showed it slows cognitive decline in early-stage Alzheimer’s patients. While we know lecanemab clears amyloid beta buildup, it was unclear how...
by Josh Meyer, Virginia Tech Credit: Unsplash/CC0 Public Domain Alzheimer’s disease is a progressive neurodegenerative disease estimated to affect 6 million Americans and 33 million people worldwide. Large numbers of those affected have not yet been diagnosed. A new study published in the Journal of Alzheimer’s Disease by a Virginia Tech Carilion School of Medicine faculty member shows...
