by Washington University School of Medicine Kanta Horie, PhD, works with a mass spectrometer that he uses to measure protein levels in cerebrospinal fluid samples. Horie and colleagues at Washington University School of Medicine in St. Louis and Lund University in Sweden have discovered that a form of the protein tau in the cerebrospinal fluid known...
In the condition, clonal hematopoiesis of indeterminate potential, or CHIP, certain blood stem cells acquire mutations that strengthen their ability to survive and multiply. As a result, the mutant cells dominate, and just a few cells can give rise to much or even all of the body’s blood and immune cells. In most cases of...
by Adam Piore, University of California, San Francisco Credit: CC0 Public Domain When Daniel Gibbs, M.D., enrolled in an Alzheimer’s study at UC San Francisco almost a decade ago, researchers needed access to a secure government facility just to confirm that he had the disease. They summoned Gibbs to the Lawrence Berkeley National Laboratory, hooked him...
In the condition, clonal hematopoiesis of indeterminate potential, or CHIP, certain blood stem cells acquire mutations that strengthen their ability to survive and multiply. As a result, the mutant cells dominate, and just a few cells can give rise to much or even all of the body’s blood and immune cells. In most cases of...
Summary: Researchers harnessed the power of artificial intelligence (AI) to measure the fluid flow around the brain’s blood vessels, a major breakthrough with far-reaching implications for treating diseases like Alzheimer’s. The team developed innovative AI velocimetry measurements to calculate this fluid flow accurately. The newly-developed technique combines 2D measurements with physics-informed neural networks to provide high-resolution insights...
by Ann Schreiber Alzheimer’s disease, the most common form of dementia, affects millions of lives worldwide, robbing patients of their memories and thinking abilities. According to the U.S. Centers for Disease Control and Prevention, nearly 6 million Americans live with Alzheimer’s disease. In this article, experts shed light on the signs of both early and late Alzheimer’s, providing...
Alzheimer disease (AD), the most common neurodegenerative disorder in the world, affects individuals of all races and ethnicities; however, most genetic research for AD has been performed on individuals of European ancestry (EA) with a limited number of large-scale genetic studies in other populations. For many centuries, Ashkenazi Jews lived in communities in Eastern Europe and were...
by University of Pittsburgh Credit: Pixabay/CC0 Public Domain Why do some people develop Alzheimer’s disease while others don’t? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates—a telltale sign of Alzheimer’s brain pathology—never go on to develop Alzheimer’s-associated dementias? University of Pittsburgh School of Medicine researchers appear to have...
By RENEE GHERT-ZAND 9 May 2023, 11:34 pm A team led by researchers at the Safra Center for Neuroscience and the Institute for Life Sciences at The Hebrew University of Jerusalem have uncovered a sex-specific molecular mechanism leading to more accelerated cognitive decline in women with Alzheimer’s disease than in men. Alzheimer’s, the leading cause of...
By WALLA! Published: MAY 2, 2023 09:04 An illustrative image of an eye(photo credit: Wikimedia Commons) The eyes are more than a window to the soul; they’re also a reflection of a person’s cognitive health. “The eye is the window into the brain,” ophthalmologist Dr. Christine Greer, Director of Medical Education at the Institute of Neurodegenerative Diseases in...
