Reviewers’ NotesReviewed by Danielle Ellis, B.Sc.Jul 31 2023 A novel vaccine that targets inflamed brain cells associated with Alzheimer’s disease may hold the key to potentially preventing or modifying the course of the disease, according to preliminary research presented at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2023. The meeting is in Boston, July...
Tag: <span>Alzheimers</span>
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Oral Tau Inhibitor Continues to Show Promise in Alzheimer’s
Megan Brooks July 21, 2023 Treatment with an experimental oral tau aggregation inhibitor, hydromethylthionine mesylate (HMTM), led to a statistically significant reduction in an established biomarker of neurodegeneration in Alzheimer’s disease (AD) in the LUCIDITY phase 3 trial. Blood concentrations of neurofilament light chain (NfL) showed a 93% reduction in change over 12 months in participants receiving...
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Enhanced light sensitivity may contribute to Alzheimer’s ‘sundowning,’ disease progression
UNIVERSITY OF VIRGINIA HEALTH SYSTEM IMAGE: HEATHER FERRIS, MD, PHD, OF THE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE’S DIVISION OF ENDOCRINOLOGY AND METABOLISM, FOUND THAT ENHANCED LIGHT SENSITIVITY MAY PLAY A KEY ROLE IN ALZHEIMER’S DISEASE. CREDIT: UVA HEALTH New Alzheimer’s research from UVA Health suggests that enhanced light sensitivity may contribute to “sundowning” – the worsening...
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Tau-based biomarker tracks Alzheimer’s progression
by Washington University School of Medicine Kanta Horie, PhD, works with a mass spectrometer that he uses to measure protein levels in cerebrospinal fluid samples. Horie and colleagues at Washington University School of Medicine in St. Louis and Lund University in Sweden have discovered that a form of the protein tau in the cerebrospinal fluid known...
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COMMON BLOOD CONDITION MAY PROTECT AGAINST ALZHEIMER’S
In the condition, clonal hematopoiesis of indeterminate potential, or CHIP, certain blood stem cells acquire mutations that strengthen their ability to survive and multiply. As a result, the mutant cells dominate, and just a few cells can give rise to much or even all of the body’s blood and immune cells. In most cases of...
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You may soon be able to get a blood test for Alzheimer’s, but will you want one?
by Adam Piore, University of California, San Francisco Credit: CC0 Public Domain When Daniel Gibbs, M.D., enrolled in an Alzheimer’s study at UC San Francisco almost a decade ago, researchers needed access to a secure government facility just to confirm that he had the disease. They summoned Gibbs to the Lawrence Berkeley National Laboratory, hooked him...
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COMMON BLOOD CONDITION MAY PROTECT AGAINST ALZHEIMER’S
In the condition, clonal hematopoiesis of indeterminate potential, or CHIP, certain blood stem cells acquire mutations that strengthen their ability to survive and multiply. As a result, the mutant cells dominate, and just a few cells can give rise to much or even all of the body’s blood and immune cells. In most cases of...
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AI Unlocks Mysteries of Brain Fluid Flow: A Leap Forward in Alzheimer’s Research
Summary: Researchers harnessed the power of artificial intelligence (AI) to measure the fluid flow around the brain’s blood vessels, a major breakthrough with far-reaching implications for treating diseases like Alzheimer’s. The team developed innovative AI velocimetry measurements to calculate this fluid flow accurately. The newly-developed technique combines 2D measurements with physics-informed neural networks to provide high-resolution insights...
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The 10 Alzheimer’s symptoms you need to know
by Ann Schreiber Alzheimer’s disease, the most common form of dementia, affects millions of lives worldwide, robbing patients of their memories and thinking abilities. According to the U.S. Centers for Disease Control and Prevention, nearly 6 million Americans live with Alzheimer’s disease. In this article, experts shed light on the signs of both early and late Alzheimer’s, providing...
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UNIQUE GENETIC RISK FOR ALZHEIMER’S FOR ASHKENAZI JEWS
Alzheimer disease (AD), the most common neurodegenerative disorder in the world, affects individuals of all races and ethnicities; however, most genetic research for AD has been performed on individuals of European ancestry (EA) with a limited number of large-scale genetic studies in other populations. For many centuries, Ashkenazi Jews lived in communities in Eastern Europe and were...