September 3, 2024 by University of Texas at Austin Graphical abstract. Credit: Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101668Researchers have discovered an antibody able to neutralize all known variants of SARS-CoV-2, the virus that causes COVID-19, as well as distantly related SARS-like coronaviruses that infect other animals. As part of a new study on hybrid immunity...
JULY 23, 2024 by Delthia Ricks , Medical Xpress Response to vedolizumab is associated with loss of lymphoid aggregate size. (A) Representative hematoxylin and eosin staining of colonic biopsies from responder (R) and nonresponder (NR) patients with UC taken before and after VDZ therapy. Lymphoid aggregate (LA) border indicated with red line. Scale bars, 100...
JUNE 1, 2024 by Bill Snyder, Vanderbilt University Medical Center A 3D rendering shows one of the isolated antibodies, FluB-393, (blue) binding to the neuraminidase surface glycoprotein (red) of the influenza type B virus to prevent infection. Credit: Elad Binshtein, Ph.D., and Anthony CzelusniakResearchers at Vanderbilt University Medical Center have isolated human monoclonal antibodies against...
by Sarah Avery, Duke University Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2023.12.002The path to a successful HIV vaccine depends on a critical first step—activating specific immune cells that induce broadly neutralizing antibodies. Reporting Jan. 4 in the journal Cell, a research team led by the Duke Human Vaccine Institute has achieved that requisite initial step in...
by Felicia Lindberg, Karolinska Institutet Credit: Pixabay/CC0 Public Domain Researchers at Karolinska Institutet and Danderyd Hospital have followed recipients of the new updated COVID-19 vaccine and analyzed the antibody response to different SARS-CoV-2 variants. The results show a surprisingly strong response to the now dominant and highly mutated omicron variants. The ongoing COMMUNITY study, which was...
by Public Library of Science Humans mount convergent H1N1-H3N2 neutralizing antibody responses to influenza virus. Panels are derived from structures reported by Simmons et al., (PDB 7TRH, 7RRI and 3UBE by Xu et al., for the model of receptor engagement). Credit: Kevin McCarthy (CC-BY 4.0, creativecommons.org/licenses/by/4.0/) Researchers have identified a previously unrecognized class of antibodies—immune system...
by University of Montreal CD47 interacts in cis with SLAMF7 on tumor cells. a, Binding of CD47-Fc (red line) to WT or Sirpa−/− BMDMs assayed by flow cytometry. Filled curves, Ctrl Fc. b, Mass spectrometry analysis of Flag mAb immunoprecipitates from L1210 derivatives expressing a Flag-tagged variant of mCD47 showing various potentially associated proteins. c, Co-IP...
by Duke University Credit: Unsplash/CC0 Public Domain For too long, cancer treatment has been a double-edged sword—the very treatments designed to kill cancer cells often wrought havoc on healthy ones too. But a new study published online Oct. 30 in Immunity unveils an approach to cancer treatment that researchers describe as more precise, long-lasting, and less...
by Translational Genomics Research Institute SIWA318H treatment depletes p16INK4a positive cells and reduces αSMA expression in PSN1 xenograft tumors. (A) Quantification of the number of p16INK4a positive cells in isotype control antibody treated and SIWA318H treated tumors. (B) Quantification of αSMA positive areas in isotype control antibody treated and SIWA318H treated tumors. (C) A representative image...
by Weill Cornell Medical College Zika virus particles (red) shown in African green monkey kidney cells. Credit: NIAID An unusual type of antibody that even at miniscule levels neutralizes the Zika virus and renders the virus infection undetectable in preclinical models has been identified by a team led by Weill Cornell Medicine, New York-Presbyterian and...
