Diagram of a HEK-beta cell. Extracellular D-glucose triggers glycolysis-dependent membrane depolarization, which activates the voltage-gated calcium channel, resulting in an influx of Calcium ions, induction of the calmodulincalcineurin signaling cascade, and PNFAT-mediated induction of insulin secretion. Researchers led by ETH Professor Martin Fussenegger at the Department of Biosystems Science and Engineering (D-BSSE) in Basel have...