by National University of Singapore Graphical abstract. Credit: Journal of Controlled Release (2023). DOI: 10.1016/j.jconrel.2023.06.035 Atherosclerosis is a disease in which fat, cholesterol, and other substances build up inside artery walls. This can lead to plaque formation, which can block arteries and cause heart attacks and strokes. Atherosclerosis is the leading cause of coronary heart disease, and is...
by The Scripps Research Institute Scientists at Scripps Research have developed molecules that can remodel the bacterial population of intestines to a healthier state and they have shown—through experiments in mice—that this reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis. The scientists, who report their findings in Nature Biotechnology, created a...
by Ludwig Maximilian University of Munich Short RNA molecules known as microRNAs (miRNAs) play a vital role in the regulation of gene expression. Anomalies in miRNAs expression and function have been implicated in pathological processes, such as the development of chronic diseases like atherosclerosis. The regulatory functions of miRNAs usually take place in the cytoplasm,...
Kathryn A. Arnold, from the University of Chicago Pritzker School of Medicine, and colleagues used deidentified, aggregate electronic medical record data from the University of Chicago and Northwestern University hospitals to identify 12,184 patients with a diagnosis of psoriasis. The researchers found that ASCVD prevalence was 2.4-fold higher among patients with psoriasis in both whites...
