September 25, 2024 Severe autoimmune conditions such as type I diabetes, Addison’s disease, lupus and inflammatory bowel disease are between two to three times more common in women who have been diagnosed with premature ovarian insufficiency (POI) compared to the general population, according to new findings. The research, published in Human Reproduction, is the largest...
Tag: <span>autoimmune diseases</span>
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Study reveals molecular mechanism behind MS and other autoimmune diseases
By Kevin Dennehy August 28, 2024 A Yale-led study reveals a mechanism that triggers loss of immune regulation associated with multiple sclerosis and other diseases — and a target for treatment. (© stock.adobe.com) More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was...
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Can autoimmune diseases be cured? Scientists see hope at last
After decades of frustration and failed attempts, scientists might finally be on the cusp of developing therapies to restore immune ‘tolerance’ in conditions such as diabetes, lupus and multiple sclerosis. Cassandra Willyard Antigen presenting cells (illustrated, right) can sometimes train T cells (left) not to attack. Credit: Juan Gaertner/Science Photo Library Back in 2001, immunologist...
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‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission
Engineered immune cells, most commonly used to treat cancers, show their power against lupus and other immune disorders. Composite coloured scanning electron micrograph (SEM) of T-cells (small round) and a cervical cancer cell (Hela) T cells (smaller cells) can be engineered to recognize cancer cells — and also other immune cells.Credit: Steve Gschmeissner/Science Photo Library...
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A common metabolite may help treat autoimmune diseases
by Hokkaido University In mice models with adoptive transfer experimental autoimmune encephalomyelitis, treatment with itaconate (right) greatly ameliorates the effects of the disease, compared to untreated mice . Credit: Kuniyuki Aso, et al. Nature Communications, February 27, 2023 Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which...
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Rogue immune cells linked to leukemia are a key driver of autoimmune diseases
GARVAN INSTITUTE OF MEDICAL RESEARCH IMAGE: A KILLER T CELL (CENTRE) HUNTING A TARGET CELL. CREDIT: NIH IMAGE GALLERY CREDIT: NIH IMAGE GALLERY Gene variants associated with leukaemia can produce ‘rogue’ immune cells that drive autoimmune diseases, according to a new study from the Garvan Institute of Medical Research. Scientists had previously noticed that leukaemia...
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New class of killer T cells may prevent autoimmune diseases
BY MITCH LESLIE 8 MAR 2022 10:00 AM A newly identified class of the human immune system’s T cells may kill other T cells, helping wind down attacks on infections and suppressing autoimmune conditions. DAVID SCHARF/SCIENCE SOURCE The price for a vigilant immune system that can pounce on tumor cells or pathogens is occasional friendly...
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Study finds vitamin D supplements with or without Omega-3s decreased risk of autoimmune diseases
by Brigham and Women’s Hospital Credit: Pixabay/CC0 Public Domain Autoimmune diseases (AD) such as rheumatoid arthritis, polymyalgia rheumatica, autoimmune thyroid disease and psoriasis, are a leading cause of morbidity and mortality as people age. Few effective treatments are available for AD, but some preclinical studies have hinted that supplements, including vitamin D and omega-3 (or...
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Researchers develop a world-first antibody-drug delivery system
IMAGE: SCHEMATIC ILLUSTRATION OF THE NEW MOF ANTIBODY CRYSTALS AND THEIR ABILITY TO SPECIFICALLY SEEK OUT CANCER CELLS TO DETECT THEM AND DELIVER HIGHLY POTENT DRUGS WITH UNPRECEDENTED PRECISION. CREDIT: DR FRANCESCO CARRARO AND PROF PAOLO FALCARO (CO-FIRST AND CO-SENIOR AUTHOR ON THE ADVANCED MATERIALS PAPER) It sounds like the stuff of science fiction: a...
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Harnessing the combined power of Vitamin C and TET proteins may give scientists a leg up in treating autoimmune diseases
by La Jolla Institute for Immunology Vitamin C is a key ingredient for immune cell function. Credit: La Jolla Institute for Immunology You can’t make a banana split without bananas. And you can’t generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears. Regulatory T cells (Tregs) help control inflammation and...