Evidence from a small-scale clinical trial suggests that a variation of the advanced blood cancer immunotherapy known as CAR-T could be adapted to treat myasthenia gravis, an autoimmune disorder of the nervous system. The modified CAR-T therapy, short for chimeric antigen receptor T-cell, used by scientists offers the potential for a longer-lasting reduction in myasthenia gravis symptoms and...
by University of Oxford Credit: Shutterstock A new population-based study of 22 million people shows that autoimmune disorders now affect about 1 in 10 individuals. The work, published in The Lancet, also highlights important socioeconomic, seasonal, and regional differences for several autoimmune disorders and provides new clues on possible causes behind these diseases. Autoimmune diseases occur when the...
by Weizmann Institute of Science Credit: Unsplash/CC0 Public Domain Supporting actors sometimes steal the show. In a new study published today in Cell, researchers headed by Prof. Ido Amit at the Weizmann Institute of Science have shown that supporting cells called fibroblasts, long viewed as uniform background players, are in fact extremely varied and vital. A...
by University of Toledo Dr. Blair Grubb, right, a cardiologist at The University of Toledo Medical Center and Distinguished University Professor in the UToledo College of Medicine and Life Sciences, and Dr. William Gunning, a professor of pathology in the UToledo College of Medicine and Life Sciences, continue to build evidence for the theory that postural...
NEWCASTLE UNIVERSITY A new study has shed light on a debilitating autoimmune condition by identifying a number of sub types of the disease which could lead to personalized treatment for patients. For the first time, scientists at Newcastle University, UK, have found there are at least four versions of primary Sjögren’s syndrome (PSS) – a...
A drug approved to treat a severe form of asthma dramatically improved the health of people with rare chronic immune disorders called hypereosinophilic syndromes (HES) in whom other treatments were ineffective or intolerable. This finding comes from a small clinical trial led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part...
Research suggests that celiac disease could be caused by a bacterial enzyme used to manufacture sausages, cheese, bread and other processed foods. FRONTIERS Myths about gluten are hard to bust. Intolerance, allergy, sensitivity, hypersensitivity. What is what? Celiac disease is none of these things. It is an autoimmune disorder, where gluten triggers the immune system to attack the gut. It is common, lifelong,...
Rheumatoid arthritis is an autoimmune disorder that causes inflammation in the joints. A doctor will diagnose rheumatoid arthritis by asking a person about their symptoms, carrying out a physical examination, taking blood tests, and using imaging studies. Doctors may test blood samples for several inflammatory and immune system compounds that are usually present in a...
Formation of extracellular structures from white blood cells, after stimulation with ANCA autoantibodies. Researchers from Charité—Universitätsmedizin Berlin have been able to improve their understanding of the key mechanism involved in the pathogenesis of a serious autoimmune disease. For the first time, researchers were able to demonstrate a close link between the activation of programmed...
