EUROPEAN ALLIANCE OF ASSOCIATIONS FOR RHEUMATOLOGY (EULAR) SAIDs are a group of multi-system disorders caused by dysfunction in the innate immune system. A number of these SAIDs are mediated by a cytokine called interleukin-1 (IL-1), including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), and deficiency of...