Australian researchers have uncovered clues in the immune system that reveal how the balance of ‘good’ gut bacteria is maintained. This information could help in the prevention and treatment of inflammatory bowel disease (IBD) WALTER AND ELIZA HALL INSTITUTE IMAGE: ASSOCIATE PROFESSOR SETH MASTERS AND DR ALAN YU. The study, published in the journal Nature Communications, showed that the increased presence of...
Tag: <span>Bowel disease</span>
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Scientists discover what drives inflammation in IBD
Researchers have recently identified a mechanism that regulates gut inflammation in inflammatory bowel disorders. The discovery may lead to better treatment and diagnosis of some conditions, such as ulcerative colitis and Crohn’s disease. IBD can reduce quality of life, so finding new treatments for it is vital. Researchers at Sanford Burnham Prebys (SBP) Medical Discovery Institute in La...
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Study shows BPA risk factor for inflammatory bowel disease
A recent study in a preclinical model of inflammatory bowel disease shows dietary exposure to bisphenol-A, or BPA, found in polycarbonate plastics and epoxy resins, can increase mortality and worsen its symptoms. Dr. Clint Allred (second from left) and colleagues in the laboratory. Credit: Texas A&M College of Agriculture and Life Sciences Dr. Clint Allred,...
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From designer microbes to stem cells, researchers are investigating new strategies to treat bowel disease
The University of Toronto’s David McMillen and his research team are creating a new life form to ward off disease – a bespoke, gut-dwelling microbe engineered to release drugs when needed. ut organoids are three-dimensional balls of intestinal tissues grown in the lab from stem cells that allow researchers to examine the role different types of cells play in...
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Why we all need to be proactive about our bowels
Inflammatory bowel disease (IBD) is a mounting burden on health-care systems globally. Manipulating environmental exposures to optimize a healthy microbiome may hold the promise of preventing chronic inflammatory diseases, such as Crohn’s disease and ulcerative colitis. Credit: Shutterstock A 2012 study found that Crohn’s disease and ulcerative colitis (two types of IBD) are significantly on...
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Colon signaling pathway key to inflammatory bowel disease
Upon inflammation, monocytes are recruited into the inflamed colon, where they become colitogenic macrophages expressing TNF-? and iNOS. Regarding the mechanisms, we found that IFN-γ acts on the recruited monocytes and phosphorylated STAT1 …more The intestine encounters more foreign substances and potential toxins than other parts of the body, so it is not surprising that a...
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Scientists develop new antibody for bowel disease
Sadikshya Bhandari, a Ph.D. student in molecular and cell biology, ‘passing cells,’ or feeding them, to keep them from overgrowing. UConn molecular and cell biologist Michael Lynes and an international team of researchers have been awarded a patent for a novel antibody therapeutic that may prove to be safer in the treatment of Inflammatory...