by Trinity College Dublin Credit: Unsplash/CC0 Public Domain A team of scientists from Trinity College Dublin and investigators from FutureNeuro has announced a major discovery with profound importance for our understanding of brain fog and cognitive decline seen in some patients with long COVID. The work appears in Nature Neuroscience.In the months after the emergence of...
By Caroline Burke Getty Images Buckle up for a surprisingly exciting crash course on serotonin. The results of a new study on long Covid are out, and they’re more than promising — they might even be groundbreaking. Conducted by researchers at the University of Pennsylvania, the study suggests there may be a strong connection between serotonin...
By Elizabeth Cooney Oct. 16, 2023 ADOBEIf you’ve been following the mystery of long Covid since it emerged in 2020, you’ll recall interferons and serotonin have been clues from the start as combatants in the body’s prolonged battles against the virus. Theories about why symptoms persist long after the acute infection has cleared often point to two...
Sara Novak July 03, 2023 Kate Whitley was petrified of COVID-19 from the beginning of the pandemic because she has Hashimoto disease, an autoimmune disorder that she knew put her at high risk for complications. She was right to be worried. Two months after contracting the infection in September 2022, the 42-year-old Nashville resident was diagnosed with...
BY CLAUDIA LOPEZ LLOREDA Mouse neurons (in magenta) fuse (yellow) when they express the SARS-CoV-2 protein and its receptor.RAMON MARTINEZ-MARMOL Of all of COVID-19’s symptoms, one of the most troubling is “brain fog.” Victims report headaches, trouble concentrating, and forgetfulness. Now, researchers have shown that SARS-CoV-2 can cause brain cells to fuse together, disrupting their communication....
by Isabella Backman, Yale University Schematic illustration of how the α2A-AR agonist, guanfacine, and the anti-oxidant NAC, can have therapeutic effects in treating the symptoms of TBI and long-COVID by strengthening PFC neurotransmission and synaptic connections and reducing neuroinflammation. Layer III dlPFC microcircuits depend on NMDAR synapses on dendritic spines to produce the persistent neuronal...
by Sarah Hellewell, The Conversation Credit: Unsplash/Uday Mittal, CC BY The COVID pandemic has introduced many scientific and medical terms into our everyday language. Many of us are now fluent in conversations about viral strains, PCR tests and mortality rates. “Brain fog” has joined these ranks to describe a now-familiar symptom of COVID and long COVID. But...
by La Trobe University Output from amyloid assembly prediction software for SARS-CoV-2 ORF6 and ORF10 sequences. a, b Outputs from amyloid predicting algorithm ZIPPER identifying hexapeptide fragments predicted to form steric zippers nucleating the assembly of amyloid fibrils. Hexapeptides with Rosetta energies below −23 kcal mol−1 are predicted to be highly amyloidogenic and are shown with...
Kelli Whitlock Burton April 01, 2022 Patients with persistent cognitive impairment months after illness with mild COVID-19 have higher levels of inflammatory markers in their cerebrospinal fluid (CSF). Researchers found elevated levels of CSF immune activation and immunovascular markers in individuals with cognitive post-acute sequelae of SARS-CoV-2 infection (PASC). Patients whose cognitive symptoms developed during...
By Elizabeth Cooney Jan. 28, 2022 Stanford neuro-oncologist Michelle Monje is studying the link between “chemo brain” and long Covid’s brain fog. Back in the pandemic’s first wave, Michelle Monje was worried about Covid-19’s power to muddle the brain. Seeing the massive inflammatory response to the virus and early signs of what became known as...
