September 20, 2024 by ETH Zurich Credit: Sohyon Lee and Berend Snijeder / ETH ZurichGlioblastoma is a particularly aggressive brain tumor that at present is incurable. Cancer doctors can extend patients’ life expectancy through operations, radiation, chemotherapy or surgical interventions. Nevertheless, half of patients die within twelve months of diagnosis. Drugs that are effective against...
September 9, 2024 by Ludwig Cancer Research Credit: Cancer Cell (2024). DOI: 10.1016/j.ccell.2024.08.012A Ludwig Cancer Research study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by interventions such as radiotherapy, surgery and immunotherapy. Led by Ludwig Lausanne’s Johanna Joyce, Spencer...
September 3, 2024 by CUNY Advanced Science Research Center Cultured p53 null OPC over-expressing PDGF-BB are highly proliferative and tend to aggregate in low-adhesion conditions. Credit: Neoplasia (2024). DOI: 10.1016/j.neo.2024.101042A new study from researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) sheds light on why certain oligodendrocyte progenitor cells...
August 8, 2024 by Steven Lee, University of Texas Health Science Center at San Antonio Sacituzumab govitecan (SG) inhibits tumor growth in a xenograft model of intracranial breast cancer. Representative bioluminescent images of control and sacituzumab govitecan treated (25 mg/kg/twice weekly) mice at the start of treatment (top panels) and 2 weeks after treatment (bottom panels)....
by Olivia Dimmer, Northwestern University Multiplex immunofluorescence staining and imaging using the COMET system platform on a human meningioma patient sample, showing SSTR2+ tumor cells (in red), expressing the hedgehog pathway activation marker sonic hedgehog (SHH, in cyan blue). Credit: Hinda NajemScientists have uncovered a genetic explanation for one subset of common brain tumors, according to...
by University of Turku Fluorine-18-labelled folate PET/CT 3D fusion image of a rat subject with a glioma visible in the central region of the brain. Credit: Maxwell Miner Folate-based radiopharmaceuticals can be used in positron emission tomography (PET) imaging to detect folate receptors in brain tumors. The discovery of folate receptors and their exploitation potential with...
by University of Gothenburg The researchers’ molecule Z4P inhibits one of the mechanisms that regulate protein production in a cancer cell. This inhibition causes the cancer cell to die. Three pictures show the spread of the tumor after 20 days of treatment on mice. Control: Untreated tumor. TMZ: Follow-up treatment solely with chemotherapy. Combo: Combination treatment with...
by Swedish Research Council Graphical abstract. Credit: Cancer Cell (2023). DOI: 10.1016/j.ccell.2023.04.010 Researchers from Uppsala University have developed a method that helps immune cells exit from blood vessels into a tumor to kill cancer cells. The goal is to improve treatment of aggressive brain tumors. The study has been published in the journal Cancer Cell. Glioblastoma is an aggressive brain tumor that...
APRIL 24, 2023 by Study Finds BALTIMORE — A “miracle” gel that cures brain tumors in mice could offer new hope for human cancer patients, a new study reveals. Researchers at John Hopkins University say the medication delivered by the substance stops 100 percent of an aggressive form of brain cancer within mice. The “striking” result provides new...
NAGOYA UNIVERSITY IMAGE: MICROSCOPIC IMAGE OF NANOWIRES CREDIT: DR TAKAO YASUI Researchers at Nagoya University in Japan have used a new device to identify a key membrane protein in urine that indicates whether the patient has a brain tumor. Their protein could be used to detect brain cancer, avoiding the need for invasive tests, and increasing...
