by Emily Caldwell, The Ohio State University This figure shows that chemotherapy treatment to combat cancer paradoxically alters the blood vessel wall to allow circulating cancer cells to adhere, thus increasing their ability to spread to distant sites. Credit: Justin Middleton, BioRender.com software A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond...
by Institute of Cancer Research Credit: Ahmad Ardity via Pixabay A simple blood test can identify specific genetic mutations in patients’ breast tumors to help guide their treatment and assess how likely patients are to relapse, a study shows. By allowing clinicians to better understand the genetic characteristics of individual breast cancers, the blood test can be used to...
BAYLOR COLLEGE OF MEDICINE A multi-institution team of researchers led by scientists at Baylor College of Medicine has discovered a genetic signature that can identify drivers of poor outcomes in advanced estrogen-receptor positive (ER+) breast cancer, which could one day lead to personalized treatment for patients. The 24-gene signature detects the presence of mutations and translocations in...
by European Molecular Biology Organization Graphical abstract. Credit: DOI: 10.15252/msb.202010141 Molecular targets for therapies that could prevent breast cancer recurrence have been identified by a group of German, Norwegian and British scientists who analyzed tumor cells that proved resistant to the original treatment. Recent advances in early detection and targeted therapy have led to a...
by Pennsylvania State University Credit: Unsplash/CC0 Public Domain Sometimes, when you look in the mirror you find your family looking back. It can be a source of pride—in some families, chins, noses, earlobes—even the way your brothers, sisters, aunts and uncles talk and laugh all seem to pass from generation to generation. But the possibility you...
By Angus Chen A clinician examines the results of a mammogram.ANNE-CHRISTINE POUJOULAT/AFP/GETTY IMAGES For years, health experts have recommended that, starting at the age of 50, every woman should get a mammogram every two years. But Christina Chapman, an oncologist and researcher at the University of Michigan, looked at the devastating disparities in breast cancer outcomes...
by Ludwig Institute for Cancer Research Credit: Unsplash/CC0 Public Domain A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy. The combination therapy, reported in the current issue of Nature Cancer, targets tumor-associated macrophages and microglia (TAMs), immune cells...
by University of Turku A malignant migrating breast cancer cell. The cytoskeleton of the cell is shown in purple and the “circulating” integrins within the cell are in green. Credit: Paulina Moreno-Layseca and Turku Bioimaging A research group at the University of Turku, Finland, has discovered a completely new mechanism that cells use to circulate integrins...
by Focused Ultrasound Foundation MR images showing reduction in size of metastatic tumors after focused-ultrasound delivery of antibody therapy through blood-brain barrier. Credit: Sunnybrook Health Sciences Centre In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver...
by Wiley Credit: Unsplash/CC0 Public Domain New research indicates that almost half of U.S. adults with breast cancer use cannabis (marijuana and hemp), most commonly alongside cancer treatment to manage symptoms and side effects. However, most patients don’t discuss their use of cannabis with their physicians. The findings are published early online in Cancer. Individuals with cancer often...
