by Peter MacCallum Cancer Centre Molecular principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adl0731 Peter Mac scientists have found a way to use the powerful gene editing tool CRISPR to silence cancer-causing gene mutations which, up to now, have remained off-limits to targeted drugs. ADVERTISING...
Tag: <span>Cancer</span>
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Lymphoedema: The ‘hidden’ cancer side-effect no one talks about
10 hours agoShareSave Katherine Wang Serenity Strull/ Getty Images Lymphoedema affects millions of people worldwide, but receives little attention (Credit: Serenity Strull/Getty Images) Patients who beat cancer can be left with an incurable, chronic and painful condition. Sufferers and doctors alike are fighting to bring this hidden condition to light. During a visit to the...
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Top cancer research advances at MSK in 2024
Peer-Reviewed Publication Memorial Sloan Kettering Cancer Center image: An immunofluorescence image of an aged mouse liver. Expression of β-galactosidase (white) and uPAR (yellow) in senescent cells serve as target for engineered CAR T cells. Elimination of these cells improved age-related metabolic dysfunction. The ability to improve age-related metabolic dysfunction by targeting senescent cells with engineered...
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King Charles is changing his diet to keep his cancer at bay—here’s what the evidence says
by Justin Stebbing, The Conversation Credit: Unsplash/CC0 Public Domain King Charles’s decision to cut red meat from his diet following his cancer treatment has sparked a frenzy of interest in the potential effect of what we eat on cancer outcomes, and how well people do after they’re diagnosed. ADVERTISING While the specific details of the king’s diagnosis and treatment remain...
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New treatment may delay cancer in high-risk myeloma
by Kelley Luckstein, Mayo Clinic Credit: Mayo Clinic A new treatment is showing promise for people with high-risk smoldering multiple myeloma (SMM). This precancerous condition can progress to active multiple myeloma, a type of blood cancer. High-risk SMM carries a higher likelihood of progression. Results from a phase 3 clinical trial, published in the New England Journal of Medicine and...
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Genetic code discovery could redefine understanding of cancer origins
by Virginia Commonwealth University Tumor cells synthesize and export Tu-Stroma to stromal cells via DDX3X-assisted exosomal packaging. Credit: Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02453-3 A group of scientists at VCU Massey Comprehensive Cancer Center has revealed a new genetic code that acts like a cancer ringleader, recruiting and deploying a gang of tumor cells to incite a biological turf...
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Remote-controlled gene therapy uses ultrasound to kill cancer
By Michael Irving December 09, 2024 An artist’s impression of CRISPR getting to work on cancer cells with the help of ultrasound pulses Wang Lab and Pepper Workshop View 1 Images A new kind of cancer gene therapy can be remotely activated at a specific part of the body. The team developed a version of CRISPR...
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New Barcode Technology Could Help Diagnose Cancer More Precisely
Posted Today A new pathology tool created at Yale harnesses barcode technology and shows potential for use in cancer diagnoses. The technology, Patho-DBiT (pathology-compatible deterministic barcoding in tissue), was discussed in a new study published in the journal Cell. Patho-DBiT reveals cellular level tissue architecture of an aggressive gastric lymphoma sample stored for 3 years. Image credit: Yale...
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Predicting cardiac issues in cancer survivors using a serum protein panel test
by St. Jude Children’s Research Hospital Using data from the St. Jude Lifetime Cohort (St. Jude LIFE), Yadav Sapkota, Ph.D., St. Jude Department of Epidemiology and Cancer Control, designed a 27-protein model capable of accurately estimating treatment-related cardiomyopathy risk in pediatric cancer survivors. Credit: St. Jude Children’s Research Hospital Early disease detection is beneficial for securing...
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AI method for detecting biliary tract cancer on IVA’s 100 list
Posted Today The Royal Swedish Academy of Engineering Sciences (IVA) has published this year’s 100 list of the most promising research projects from Sweden’s colleges and universities. All applications to the list have been reviewed by IVA’s expert group and the selected projects are considered to have great potential to benefit society. The list includes several...