by Jim Stallard, Memorial Sloan Kettering Cancer Center Molecular characterization of PtPM and RPM primary prostate tumor transplants demonstrates emergence of neuroendocrine carcinoma marker expression. Credit: Nature Cancer (2024). DOI: 10.1038/s43018-024-00838-6 A scientist whose discoveries about prostate cancer have led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate...
Tag: <span>Cancer</span>
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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?
by Sathana Dushyanthen and David Kok, The Conversation Comparison of differences between traditional radiotherapy and stereotactic radiotherapy. Credit: Precision Radiation Oncology Prostate cancer is Australia’s most commonly diagnosed cancer. One in six men will be diagnosed by the time they turn 85. Cancers are abnormal groups of cells that grow uncontrollably and start invading neighboring sites. They can also spread to...
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Regulations of m6A and other RNA modifications and their roles in cancer
by Frontiers Journals Credit: Frontiers of Medicine (2024). DOI: 10.1007/s11684-024-1064-8 Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A comprehensive review published in Frontiers of Medicine reveals the significant role of various RNA modifications in cancer development and progression. The review particularly focuses...
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ACOG Updates Breast Cancer Screening Guidelines
The American College of Obstetricians and Gynecologists (ACOG) has updated its breast cancer screening guidelines, recommending that individuals at an average risk for breast cancer initiate mammography screening at age 40. This change reflects evolving evidence that starting earlier screening yields greater net benefits in reducing breast cancer mortality, particularly for certain racial groups with higher...
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New CAR-T cells offer on-demand control for cancer treatment
Credit: Pixabay/CC0 Public Domain Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells—a type of cancer immunotherapy—that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs. The design and preclinical evaluation of the CAR-T cells, led by Melita Irving and Greta...
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Understanding the maturation of white blood cells to find new therapies against lymphoblastic leukaemia
Josep Carreras Leukaemia Research Institute image: The Chromatin biology laboratory, led by Dr. Alejandro Vaquero, from the Josep Carreras Leukaemia Research Institute Credit: Josep Carreras Leukaemia Research Institute Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukaemia (B-ALL) next year in Spain, according...
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Next-gen cell-penetrating antibodies for tumor targeting and RAD51 inhibition
“Overall, the data presented in this study affirm that humanizing 3E10 preserves its crucial biological properties essential for therapeutic efficacy.” Impact Journals LLC image: Figure 1: 3E10 humanization and heavy and light chain variant screening. (A) Diagram of the 3E10 antibody engineering process. The original murine wild-type 3E10 was modified to contain a human IgG1 Fc...
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How cancer cells may be using ribosomes to hide from the immune system
A ribosome, its different parts depicted in different colors. Ribosomes are the protein factories of our body’s cells. Credit: Netherlands Cancer Institute The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these ribosomes to boost...
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Colorectal cancer diagnosis found to impact lives of younger adults differently than older adults
Credit: Andrea Piacquadio from Pexels Younger adults with colon cancer tend to be diagnosed at a later stage and have more aggressive types of tumors. Additionally, young patients living with colorectal cancer have long-term, adverse consequences on their lives, which are different from the impact the disease has on older adults, according to two studies...
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Researchers suggest rethinking ‘cancer’ label for early-stage prostate changes
A new paper in the Journal of the National Cancer Institute indicates that patients may benefit if doctors stop calling certain early-stage changes to the prostate “cancer” at all. The paper is titled “When is prostate cancer really cancer?”. Prostate cancer is the second leading cause of cancer death worldwide in men, but far more...