by Justin Jackson, Medical Xpress Study and analysis designs. a, Breakdown of the histological disease states among patients with Barrett’s esophagus in the Cambridge selected cross-sectional study, representing the highest disease state for that patient. NDBE, non-dysplastic Barrett’s esophagus. b, The FHCC cohort consisted of 80 patients for whom biopsies were collected prospectively. The cohort...
by Northwestern University Mitochondria. Credit: Wikipedia commons A change in function in a mitochondrial antioxidant protein increases stem cell gene expression that promotes the development of more aggressive cancerous cells, according to a recent Northwestern Medicine study published in Proceedings of the National Academy of Sciences. While the protein superoxide dismutase-2 (SOD2) has been known to...
by Hudson Institute of Medical Research L-R: Professor Brendan Jenkins, Dr Ruby Dawson. Credit: Hudson Institute of Medical Research Researchers aim to beat stomach cancer at its own game by identifying modulators of the innate immune system that drive it and applying the brakes before cancer takes hold. In 2021, Professor Brendan Jenkins and Dr....
BECKMAN INSTITUTE FOR ADVANCED SCIENCE AND TECHNOLOGY IMAGE: JEFFERSON CHAN (LEFT), AN ASSOCIATE PROFESSOR OF CHEMISTRY AT THE UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN, AND ANUJ YADAV (RIGHT), A SENIOR RESEARCH ASSOCIATE, WERE PART OF A TEAM THAT DEMONSTRATED A DIRECT LINK BETWEEN A HIGH-FAT DIET AND HEIGHTENED NITRIC OXIDE LEVELS, WHICH CAN LEAD TO INCREASED RISK...
by Federico Graciano, Duke-NUS Medical School CRISPRi screens to identify functional Wnt-regulated lncRNAs that are important for pancreatic cancer growth in different models. Credit: Excerpted from Figure 4 in Liu, S., Harmston, N., Glaser, T.L. et al. Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. Genome Med 12, 89 (2020). doi:10.1186/s13073-020-00788-5, under...
