The PER-seq measured error signature of Pol ε P286R resembles the mutational spectrum and mutational signatures of POLEd and MMRd human cancers. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01945-x A Ludwig Cancer Research study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome—one that contributes to many...
Tag: <span>cancer genome</span>
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568 genes identified with the potential to trigger cancer
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) ANALYSIS OF THE GENOMES OF 28,000 TUMORS FROM 66 TYPES OF CANCER. view more CREDIT: IRB BARCELONA Cancer is a group of diseases characterised by uncontrolled cell growth caused by mutations, and other alterations in the genome of cells. A tumour can present from hundreds to thousands of...
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New tumor-driving mutations discovered in the under-explored regions of the cancer genome
by Ontario Institute for Cancer Research In an unprecedented pan-cancer analysis of whole genomes, researchers at the Ontario Institute for Cancer Research (OICR) have discovered new regions of non-coding DNA that, when altered, may lead to cancer growth and progression. The study, published today in Molecular Cell, reveals novel mechanisms of disease progression that could...