by Melissa Rohman, Northwestern University An in vivo genome-wide CRISPR-Cas9 KO screen identifying CTC-promoting genetic factors. (A) Experimental design of the genome-wide CRISPR-Cas9 KO screen focused on CTCs. (B) Primary tumor growth curves of the immunocompromised mice subcutaneously transplanted with either the TKOv3-transduced PC-3M cells or the control cells (n = 3 for each group)....
by Agency for Science, Technology and Research (A*STAR), Singapore Graphical abstract. Credit: Nucleic Acids Research (2022). DOI: 10.1093/nar/gkac479 Scientists from A*STAR’s Institute of Molecular and Cell Biology (IMCB) and Genome Institute of Singapore (GIS), as well as the NUS Cancer Science Institute of Singapore (CSI Singapore), National Cancer Center Singapore (NCCS) and Nanyang Technological University (NTU), have...
by Rachel Sauer, CU Anschutz Medical Campus Graphical abstract. Credit: Journal of Medicinal Chemistry (2022). DOI: 10.1021/acs.jmedchem.1c01778 An enzyme that has been identified as instrumental in the progression of many types of cancer is meeting its match in inhibitors synthesized and evaluated by University of Colorado (CU) Cancer Center researchers. In findings recently published in the Journal of...
TECHNICAL UNIVERSITY OF MUNICH (TUM) IMAGE: PROF. ACHIM KRÜGER AND HIS TEAM AT TUM’S UNIVERSITY HOSPITAL KLINIKUM RECHTS DER ISAR HAVE IDENTIFIED THE PROTEIN TIMP1 AS A FACTOR, WHICH CAN EXPLAIN THE SEX-SPECIFIC DIFFERENCE IN CANCER MORTALITY AND ALSO IMPROVE THE RISK-DIAGNOSTICS FOR THE CLINICAL COURSE OF THE DISEASE. THE IMAGE SHOWS PROF. KRÜGER, CELINA...
by Nagoya University Representative images of human colon cancer tissue showing the localization of gremlin 1-positive (left) and meflin-positive (right) cancer-associated fibroblasts (CAFs) in the stroma. Brown denotes CAFs that are positive for gremlin 1 or meflin T., tumor cells. Credit: Atsushi Enomoto Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two...
NAGOYA UNIVERSITY IMAGE: REPRESENTATIVE IMAGES OF HUMAN COLON CANCER TISSUE SHOWING THE LOCALIZATION OF GREMLIN 1-POSITIVE (LEFT) AND MEFLIN-POSITIVE (RIGHT) CANCER-ASSOCIATED FIBROBLASTS (CAFS) IN THE STROMA. BROWN DENOTES CAFS THAT ARE POSITIVE FOR GREMLIN 1 OR MEFLIN T.,TUMOR CELLS CREDIT: ATSUSHI ENOMOTO Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two...
TOKYO MEDICAL AND DENTAL UNIVERSITY IMAGE: IN THIS STUDY WE IDENTIFIED ISOXSUPRINE, A Β2-ADRENERGIC RECEPTOR AGONIST AS AN EFFECTIVE INHIBITOR OF MESENCHYMAL PHENOTYPES AND MIGRATION OF ORAL SQUAMOUS CELL CARCINOMA CELLS SUGGESTING THAT Β2-ADRENERGIC RECEPTOR SIGNAL. CREDIT: DEPARTMENT OF BIOCHEMISTRY,TMDU Researchers from Tokyo Medical and Dental University (TMDU) find that stimulating a group of cellular...
by Scott Schrage, University of Nebraska-Lincoln A rendering of B lymphocytes, the white blood cells responsible for producing antibodies to fight infections. Recent research led by Nebraska virologists has found that an overabundance of B lymphocytes infected with the Epstein-Barr virus contributed to the recurrence of multiple sclerosis-like symptoms in mice. Credit: Shutterstock A recent...
by Sanford Burnham Prebys Medical Discovery Institute An enzyme that blocks the metabolic processes that contribute to the rapid growth and spread of liver cancer has been discovered, according to a study by researchers at Sanford Burnham Prebys and Weill Cornell Medicine. The findings, published in Cancer Cell, could spur development of new therapies for...
Autologous Mesenchymal Stem Cells to Provide Immune Support Against COVID-19 HOUSTON, April 6, 2020 — Hope Biosciences, a clinical stage biotechnology company focused on developing cell-based therapeutics for acute and chronic disease, today announced that FDA has approved a Phase II clinical trial evaluating efficacy and safety of Hope Biosciences’ autologous, adipose-derived mesenchymal stem cells...
