by deCODE genetics Cumulative incidence of cancer among carriers and noncarriers. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01966-6. https://www.nature.com/articles/s41588-024-01966-6 Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title “Gene-based burden tests of rare germline variants identify six cancer susceptibility genes.”...
Tag: <span>cancer risk</span>
Post
Metabolic syndrome factors linked to increased bowel cancer risk
Credit: Pixabay/CC0 Public Domain Metabolic disorders such as obesity, high blood pressure and non-alcoholic fatty liver diseases have been directly linked to an increased risk of developing bowel cancer, warn Flinders University researchers. Bowel, or colorectal, cancer is the second deadliest and fourth most common type of newly diagnosed cancer in Australia with more than 15,000 Australians...
Post
Change your lifestyle to reduce your cancer risk: Expert explains how
September 18, 2024 by Mayo Clinic Credit: CC0 Public DomainRoughly one-third to one-half of cancer cases are preventable, according to the World Health Organization. Jon Ebbert, M.D., medical director of the Mayo Clinic Nicotine Dependence Center, says it’s never too late to make lifestyle changes that can decrease your risk of cancer. What do tobacco,...
Post
Fasting’s effects on stem cells linked to increased cancer risk
By Michael FrancoAugust 27, 2024 Fasting for some period of time has been shown to have certain health benefits, but if a new mouse study applies to humans, the practice may also hold some risksDepositphotos A new study from MIT has revealed the exact mechanism by which fasting causes intestinal stem cells to regenerate, which...
Post
Benign nail condition linked to rare syndrome that greatly increases cancer risk
MAY 20, 2024 by National Institutes of Health A fingernail with onychopapilloma. Credit: Dermatology Consultation Service, NIAMS Scientists at the National Institutes of Health (NIH) have discovered that the presence of a benign nail abnormality may lead to the diagnosis of a rare inherited disorder that increases the risk of developing cancerous tumors of the...
Post
Potato chip breakthrough crunches cancer risk for healthier snack
By Bronwyn Thompson Scientists take the chip off the old block and remake it without its carcinogenic potentialDepositphotosIn what many of us would consider a true public service to one of the world’s best food groups, scientists have flicked the switch on a mechanism that causes cold-stored potatoes to produce the carcinogen acrylamide. Growing these genetically...
Post
Alterations in the blood immune system found to increase cancer risk
by Germans Trias i Pujol Research Institute Pleiotropic RNYs are linked to SLE risk and plasma RNYs are relatively abundant preceding breast cancer diagnosis. a Scatter plot of the correlation of the levels of expression between RO60 and the pleiotropic or non-pleiotropic RNY signatures in TCGA normal tissue. The PCCs and p values are indicated....
Post
Study discovers 103 genes that cause inherited diseases when mutated can also increase cancer risk
by The Spanish National Cancer Research Centre Systematic analysis of the enrichment of rare pathogenic variants in cases compared to control samples. a Proposed hypothesis that rare pathogenic variants in Mendelian disease-associated genes (OMIM genes) increase the risk of cancer. b Overview of the case–control analysis. Principal components analysis (PCA) using common variants was performed to...
Post
New research advances understanding of cancer risk in gene therapies
by University of York Landscape of somatic mutations in SCD. a, Dot-plot showing the number of mutations per HSPC for each patient plotted against the patient age at the time of sampling. SNV mutation burdens of individual HSPC colonies from before GT, with correction for coverage, are displayed per patient. Mean mutation burdens per individual are...
Post
Cardiorespiratory Fitness Linked to Cancer Risk, Mortality?
Megan Brooks July 05, 2023 TOPLINE: Higher levels of cardiorespiratory fitness (CRF) may offer protection from colon and lung cancer and from lung and prostate cancer mortality among men, a large Swedish cohort study suggests. METHODOLOGY: A prospective cohort study included 177,709 Swedish men (mean age, 42; mean body mass index [BMI], 26 kg/m²) who completed an occupational health profile...