by University of California – Riverside Cartoon illustrates the research. Credit: Isaac Rodriguez, UC Riverside. In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A University of California, Riverside team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development....
Tag: <span>Cancer Therapy</span>
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Unlocking the potential of bispecific antibody-drug conjugates for targeted cancer therapy
by Frontiers Journals Credit: Unsplash/CC0 Public Domain Antibody-drug conjugates (ADCs) have emerged as a promising approach in cancer therapy, offering a ‘magic bullet’ strategy that combines the precision of monoclonal antibodies with the potency of cytotoxic drugs. The evolution of ADCs has seen significant advancements from first-generation Mylotarg, which was initially approved and later withdrawn...
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FDA is investigating whether CAR-T, a cancer therapy pioneered at Penn, can cause lymphoma
by Sarah Gantz, The Philadelphia Inquirer Hodgkin lymphoma, nodular lymphocyte predominant (high-power view) Credit: Gabriel Caponetti, MD./Wikipedia/CC BY-SA 3.0 The University of Pennsylvania plans to continue offering CAR-T therapy, a cancer treatment pioneered at Penn, after the Food and Drug Administration announced an investigation into whether the treatment may cause cancer in rare cases. Chimeric...
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Cancer therapy shows promise against tuberculosis
by Texas Biomedical Research Institute Credit: Biomedicine & Pharmacotherapy (2023). DOI: 10.1016/j.biopha.2023.115738A promising new cancer therapy also appears extremely potent against one of the world’s most devastating infectious diseases: tuberculosis (TB). Scientists at Texas Biomedical Research Institute (Texas Biomed) have found that the therapy dramatically reduces TB growth, even for bacteria that are drug-resistant. The...
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Common blood thinner may double as cancer therapy
by Columbia University Irving Medical Center Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.06.014 Warfarin, a widely used blood thinner, appears to have potent anti-cancer properties, according to a study by Columbia University researchers. The study, conducted in human cells and in mice, found that warfarin stops tumors from interfering with a self-destruct mechanism that cells initiate when they detect mutations...
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Rethinking the protein inhibitor approach to cancer therapy
by Stony Brook University Two-step strategy for repeatable site-specific gene circuit integration. a, Network diagram of regulatory interactions and phenotypic impacts for native and ectopic BACH1. ‘BACH1e’ indicates the ectopic BACH1 gene introduced and controlled via the mNF gene circuit, whereas ‘BACH1n’ indicates the native BACH1 gene; ‘BACH1p’ indicates the BACH1 protein. The same notation applies to...
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Failed cancer therapy revived as powerful tumor killer when combined with newer drugs
16 MAY 2023 5:50 PM BY MITCH LESLIE Drugs that prevent new blood vessel growth may make tumors more vulnerable to checkpoint inhibitors. ELLA MARU STUDIO/SCIENCE SOURCE Patients with a type of liver cancer known as hepatocellular carcinoma (HCC) often face an anxious wait after their tumor is removed. In up to half of these...
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Novel biomimetic polypeptides activate tumor-infiltrating macrophages, offering hope for cancer therapy
NANJING AGRICULTURAL UNIVERSITY THE ACADEMY OF SCIENCE IMAGE: THE TFOLD-PREDICTED PROTEIN STRUCTURE OF A BMPP COMPRISING (GGSGGPGGGPASAAANSASRATSNSP)N, THE RGD MOTIF FROM COLLAGEN AND THE IKVAV MOTIF FROM LAMININ, DESIGNED BY A RESEARCH TEAM FROM CHINA. BMPPS CAN ACTIVATE THE M1 PHENOTYPE OF MACROPHAGES, WHICH CAN BE USED FOR IMMUNOTHERAPY AGAINST CANCER. CREDIT: NA KONG FROM...
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Blocking DNA production in cancer therapy by targeting the POLtheta enzyme
CEMM RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES IMAGE: SARA BERNARDO, JOANNA I. LOIZOU, ANNA SCHREMPF CREDIT: DOMINIK KIRCHHOFER, KLAUS PICHLER, LAURA ALVAREZ/CEMM In a recent study, researchers from Joanna Loizou’s group from CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, and the Medical University of...
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Sugar molecules as a target in cancer therapy
UNIVERSITY OF BASEL Cancer cells use sugar molecules on their surface to disable attacks by the body’s immune system. Researchers at the University of Basel now report on how this mechanism can be neutralized. The immune system is actually extremely well equipped to get rid of abnormal cells. As a safety mechanism, special features are...