by University of Tokyo An overview of the researchers’ ideas. Credit: 2024 Ivana Duic Urushibata. CC-BY-ND Cellular death is a fundamental concept in the biological sciences. Given its significance, its definition depends on the context in which it takes place, and lacks a general mathematical definition. Researchers from the University of Tokyo propose a new mathematical...
Tag: <span>cell death</span>
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New study reveals mechanism of cell death in melanoma cells by cannabis extract
by Charles Darwin University Graphical abstract. Credit: Cells (2024). DOI: 10.3390/cells13030268A cannabis extract has shown positive results in slowing down melanoma cell growth and increasing cell death rates, a new in-vitro study finds. Researchers from Charles Darwin University (CDU) and RMIT investigated programmed cell death caused by a specific cannabis extract (cannabinoid PHEC-66) from the cannabis...
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Researchers identify protein complex critical in helping control cell death
UNIVERSITY OF SOUTH FLORIDA (USF HEALTH) IMAGE: ZHIGAO WANG, PHD, ASSOCIATE PROFESSOR OF CARDIOVASCULAR SCIENCES, IN HIS LABORATORY AT THE USF HEALTH HEART INSTITUTE, UNIVERSITY OF SOUTH FLORIDA. IMAGES ON THE MONITOR DEPICT TWO TYPES OF CELL DEATH: APOPTOSIS (LEFT) AND NECROPTOSIS. CREDIT: USF HEALTH/UNIVERSITY OF SOUTH FLORIDA TAMPA, Fla. (Feb. 18, 2022) – Cell death...
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Molecular ‘culprit’ caught driving cell death and inflammation
by Walter and Eliza Hall Institute of Medical Research Graphical abstract. Credit: DOI: 10.1016/j.immuni.2022.01.003 A WEHI-led study has identified a molecular ‘culprit’ responsible for causing damaging levels of cell death and inflammation in the body. The findings could lead to improved treatment options for a range of conditions driven by inflammatory cell death, including the...
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Old protein – new function: tBID can directly trigger cell death
UNIVERSITY OF COLOGNE The protein tBID can trigger programmed cell death (apoptosis) by inducing damage in the energy suppliers of the cells, the mitochondria. Apoptosis is essential for maintaining tissue balance. In addition, apoptosis plays a critical role as a defence mechanism and in the elimination of damaged or redundant cells in our bodies. Impaired...
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Is it Possible to Safely Tip the Balance in Cancer Treatment Towards Cell Death Rather than Cell Senescence?
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an...
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CELLS UNDERGOING CELL DEATH PROTECT THEIR NEIGHBORS TO MAINTAIN TISSUE INTEGRITY
To enable tissue renewal, human tissues constantly eliminate millions of cells, without jeopardizing tissue integrity, form, and connectivity. The mechanisms involved in maintaining this integrity remain unknown. Scientists from the Institut Pasteur and the CNRS today revealed a new process that allows eliminated cells to temporarily protect their neighbors from cell death, thereby maintaining tissue...
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A key player in cell death moonlights as a mediator of inflammation
KANAZAWA UNIVERSITY IMAGE: Caspase-1, a protease of the caspase family, is activated in response to microbial infections, cellular stresses, and so on, through inflammasome activation, resulting in the maturation of the key pro-inflammatory cytokines IL-1α and IL-1β. Although caspase-1 directly processes pro-IL-1β into the mature form, pro-IL-1α is not a substrate for caspase-1. It has...
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Study finds that regulatory protein prevents signaling that triggers cell death
by Leigh MacMillan, Vanderbilt University The team studying the regulation of innate immune response includes (front row, from left) Yang Zhao, Ph.D., Antiana Richardson, (back row, from left) William Dunker, Xiang Ye, Ph.D., and John Karijolich, Ph.D. Credit: Susan Urmy A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) prevents the activation of an...
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A targeted treatment for emphysema? Small engineered peptide maintains lung tissue in animal models
by Children’s Hospital Boston Children’s Hospital tested PR1P in lung cells and mouse models of emphysema, they found that it protected VEGF from being degraded, prevented cell death, and protected the lung. Credit: Hao Wu, PhD, Boston Children’s Hospital Emphysema is a progressive, debilitating lung disease in which the lung’s breathing sacs, or alveoli, enlarge,...
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