by Olivia Dimmer, Northwestern University Tissue-restricted expression of mammalian HAPSTR2. a Transcript abundance of HAPSTR1 and HAPSTR2 in the indicated human tissues; GTEx RNA-seq data. TPM, transcripts per million. Same heatmap scale across other subpanels. b Gene expression, chromatin accessibility, transcription start sites, and CpG islands at human HAPSTR1 and HAPSTR2 gene loci; GTEx, ENCODE,...
by University of Barcelona The study identifies the cytokine GDF15, a protein whose expression increases in response to cellular stress, as a key factor for the metformin drug to show antidiabetic effects. Credit: Pharmacological Research (2022). DOI: 10.1016/j.phrs.2022.106578 Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the...
UNIVERSITY OF CALIFORNIA – IRVINE IMAGE: SHOWN IS A SURFACE RENDERING OF G3BP1 GRANULES (IN GREEN) DETECTED BY IMMUNOFLUORESCENCE IN THE HD MOUSE MODEL CORTEX. CREDIT: UCI SCHOOL OF MEDICINE Irvine, CA – June 23, 2021 – A new University of California, Irvine-led study finds that the persistence of a marker of chronic cellular stress,...
